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Enzyme inducer

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Anenzyme inducer is a type ofdrug that increases themetabolic activity of an enzyme, either bybinding to theenzyme and activating it, or by increasing the expression of the gene coding for the enzyme.[1][page needed] One of the examples of enzyme inducers can be Cytochrome P450[2] enzymes, which will help tometabolize the drugs faster in the organism.

Enzyme inducers are important in the pharmaceutical field to learn drug interactions.[3] Studies show that certain drugs will increase the activity of the inducer, examples could be antibiotics.[4] It is the opposite of anenzyme repressor. There are specific types of enzyme inducers[5] that createcytoprotective pathways that play a role in prevention and treatment of cancer and other diseases includingcardiovascular disease andneurodegenerative diseases.

Enzyme inducers can be either naturally occurring or synthetically made. These inducers can be naturally occurring, like compounds incruciferous vegetables, orsynthetically developed fortherapeutic purposes.

See also

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References

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  1. ^Stanbury PF, Whitaker A, Hall SJ (2013).Principles of Fermentation Technology (2nd ed.). Elsevier.ISBN 9781483292915. Retrieved1 August 2016.
  2. ^Jing Li; Chengde Zhang; Shiwen Wu, Jiao Xue; Ke Chen; Zixin Deng; Dongqing Zhu (May 5, 2025)."Science Direct".login.proxy.wexler.hunter.cuny.edu. Retrieved2025-05-03.{{cite web}}: CS1 maint: multiple names: authors list (link)
  3. ^Hakkola, Jukka; Hukkanen, Janne; Turpeinen, Miia; Pelkonen, Olavi (May 5, 2025)."Inhibition and induction of CYP enzymes in humans: an update".Archives of Toxicology.94 (11):3671–3722.doi:10.1007/s00204-020-02936-7.ISSN 1432-0738.PMC 7603454.PMID 33111191.
  4. ^Chandra, D, Kale, RK."Web of Science".login.proxy.wexler.hunter.cuny.edu. Retrieved2025-05-03.{{cite web}}: CS1 maint: multiple names: authors list (link)
  5. ^Dinkova-Kostova, Albena T (2010)."Exceptionally Potent Inducer of Cytoprotective Enzymes: ELUCIDATION OF THE STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1".The Journal of Biological Chemistry.285 (44):33747–33755.doi:10.1074/jbc.M110.163485.PMC 2962473.PMID 20801881.

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