Anendocannabinoid enhancer (eCBE) is a type ofcannabinoidergic[1]drug that enhances the activity of theendocannabinoid system by increasingextracellularconcentrations ofendocannabinoids.[2][3][4][5] Examples of different types of eCBEs includefatty acid amide hydrolase (FAAH)inhibitors,monoacylglycerol lipase (MAGL)inhibitors, andendocannabinoid transporter (eCBT) inhibitors (or "endocannabinoid reuptake inhibitors" ("eCBRIs")).[2][3][4][5] An example of an actual eCBE isAM404, theactive metabolite of theanalgesicparacetamol (acetaminophen; Tylenol) and a dual FAAH inhibitor and eCBRI.[6][7][8]
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