Falco was born in the New York City borough ofBrooklyn on July 5, 1963, the daughter of Judith Anderson, an actress, and Frank Falco, a jazz drummer who later worked for an advertising agency.[9][10] Her father was of Italian descent and her mother had Swedish, English andCornish (1/16th) ancestry.[11][12][13] She has two brothers, Joseph and Paul, and a sister, Ruth. Her uncle is novelist, playwright, and poetEdward Falco. In 2012, Falco was the subject of an episode ofWho Do You Think You Are? which focused on one of her ancestors, a Cornishmaster mariner fromPenzance who was born at sea and died in 1840.[14][15][16]
Early in her career, Falco made appearances on television shows likeLaw & Order andHomicide: Life on the Street.Tom Fontana, executive producer ofHomicide, cast Falco as Eva Thormann, the wife of an injured police officer, after watching Falco's performance inLaws of Gravity, a 1992 film directed byNick Gomez. Fontana said of her, "She's an actress who's unadorned by any embroidery. She does everything with such simplicity and honesty, it's breathtaking."[21] A struggling actress at the time, Falco said her salary from these television episodes paid for one month's worth of rent.[22] She debuted on the big screen in 1987'sSweet Lorraine starringMaureen Stapleton.[23]
Later, she had a small speaking role in theWoody Allen comedy filmBullets Over Broadway (1994). Her friendship with formerSUNY Purchase classmateEric Mendelsohn, who was the assistant to Allen's costume designer, Jeffrey Kurland, helped her to be cast in the role. Mendelsohn went on to direct Falco in his feature filmJudy Berlin, for which he won Best Director honors at theSundance Film Festival. Falco would later go on to star in Mendelsohn's next film3 Backyards, for which he won Best Director a second time.[24]
As of 2008, Falco,The X-Files starGillian Anderson,Ugly Betty starAmerica Ferrera, and30 Rock'sTina Fey were the only actresses to have received aGolden Globe, anEmmy, and aSAG Award in the same year. Falco won these awards in 2003 for her performance as Carmela Soprano during the fourth season ofThe Sopranos. In the show's final season Alessandra Stanley ofThe New York Times wrote, "The series has always distinguished itself by the quality of its actors, but this season Ms. Falco depicts even more deeply than before, if that's possible, the full range of a mother and wife's anguish."[32]
Falco starred as the title character, Nurse Jackie Peyton, in theShowtimedark comedy seriesNurse Jackie, which premiered on June 8, 2009, and ended on June 28, 2015. For the first season, she won her fourthPrimetime Emmy Award, this time forOutstanding Lead Actress in a Comedy Series. She also received nominations for fourGolden Globe Awards and eightScreen Actors Guild Awards.[36][37][38] Alessandra Stanley ofThe New York Times wrote, "It's the compelling, enigmatic heroine who holds the errant pieces together. Jackie is not Carmela, but Ms. Falco brings some of Carmela's prosaic manner and harsh certainty to the new role. Jackie has a very dry and mitigating sense of humor, but her righteous streak steers the story."[39]
It was announced in January 2013 that Falco would star in Liz Flahive'sThe Madrid off-Broadway. The limited engagement, directed by Leigh Silverman, began previews on February 5 with an official opening on February 26. Along with Falco, the play starred John Ellison,Christopher Evan Welch, Phoebe Strole, andFrances Sternhagen.[44] In 2016, Falco started portraying Sylvia Wittel on theLouis C.K. seriesHorace and Pete acting alongside C.K.,Steve Buscemi,Alan Alda andLaurie Metcalf. The first episode was released on January 30, 2016, on C.K.'s website without any prior announcements.[45] New episodes premiered weekly until the tenth episode was released on April 2, 2016.[46] In the series, Falco portrayed Horace and Sylvia's abused mother. James Poniewozik ofThe New York Times noted "Louis C. K. is reportedly submittingHorace and Pete for the Emmys as a drama. If it gets a nomination — Mr. Alda, Mr. Buscemi, Ms. Falco and Ms. Metcalf would all be strong picks".[47]
In 2020, she appeared as the lead character in thePaul AttanasioCBS police dramaTommy. Falco originally reprised her breakout role asCarmela Soprano for the 2021 filmThe Many Saints of Newark, a prequel toThe Sopranos. However, her scenes were cut from the finished film.[53] Falco also starred in the FX true crime seriesImpeachment: American Crime Story (2021) portrayingHillary Rodham Clinton oppositeClive Owen'sBill Clinton andBeanie Feldstein'sMonica Lewinsky. Ines Bellina ofA.V. Club wrote, "Falco expertly guides us through a whole smorgasbord of human emotions. From rage to heartache to regret to shame to longing to pride to a pure, pure ache, we ride that emotional roller coaster firmly by her side".[54] In 2023 she played Amy Davidson, a fictional version ofPete Davidson's mother, in his semi-autobiographical seriesBupkis onPeacock. It was announced in May 2024 that the series had ended after its first season.[55]
She is avegan and has worked withPETA on projects, including a public-service message urging parents to keep their children away from the circus.[62] She toldParade magazine, "I believe this is at the base of everything bad in society—you can bring it back to cruelty to animals. If you don't have respect for the life of any kind, it will manifest in more obvious ways."[63]
During the2004 U.S. presidential election, Falco appeared in a 30-second television commercial on behalf of Mothers OpposingBush in which she said, "Mothers always put their children first. Mr. Bush, can you say the same?"[64] Falco has become the spokesperson forHealth Care for America Now and appeared onCNN on June 25, 2009.[65]
Falco has struggled withalcoholism and decided to become sober in the early 1990s after "one particular night of debauchery." She said in an interview that it was difficult to be around the hard-partying cast ofThe Sopranos, stating, "This cast, in particular, they really love to hang out and party. They make it look like fun. And it was fun for me! They spend a lot more time without me than with me, by my own choice. I'm always invited, and I'm always there for two minutes and I leave, because I can't live in that world anymore. It's too dangerous."[66] She is an advocate ofAlcoholics Anonymous' 12-step program.[67]
In 2003, Falco was diagnosed withbreast cancer. She chose not to make the news public until the following year.[66]