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Eberconazole

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Eberconazole
Clinical data

Trade names	Ebernet
Legal status
Legal status	US: Not FDA approved
Identifiers
IUPAC name 1-(1,3-Dichloro-6,11-dihydro-5H-dibenzo[1,2-a:1',4'-e] [7]annulen-11-yl)imidazole
CAS Number	128326-82-9
PubChemCID	72051
ChemSpider	65038
UNII	V7O1U41C9B
CompTox Dashboard(EPA)	DTXSID90926104
Chemical and physical data
Formula	C₁₈H₁₄Cl₂N₂
Molar mass	329.22 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CC2=CC(=CC(=C2C(C3=CC=CC=C31)N4C=CN=C4)Cl)Cl
InChI InChI=1S/C18H14Cl2N2/c19-14-9-13-6-5-12-3-1-2-4-15(12)18(17(13)16(20)10-14)22-8-7-21-11-22/h1-4,7-11,18H,5-6H2 Key:MPTJIDOGFUQSQH-UHFFFAOYSA-N

Eberconazole is anantifungal drug. As a 1%topical cream, it is an effective treatment fordermatophytosis,candidiasis, andpityriasis.^[1]^[2]^[3]

It was approved for use in Spain in 2015 and is sold under the trade name Ebernet.^[4] It is also approved for use in Panama, Guatemala, Costa Rica, Honduras, and the Dominican Republic.^[1]

References

[edit]

^^a ^b"Ebernet". NewBridge Pharmaceuticals. Archived fromthe original on 2016-04-24. Retrieved2017-01-15.
^del Palacio A, Ortiz FJ, Pérez A, Pazos C, Garau M, Font E (2001). "A double-blind randomized comparative trial: eberconazole 1% cream versus clotrimazole 1% cream twice daily in Candida and dermatophyte skin infections".Mycoses.44 (5):173–80.doi:10.1046/j.1439-0507.2001.00632.x.PMID 11486455.
^Repiso Montero T, López S, Rodríguez C, del Rio R, Badell A, Gratacós MR (May 2006). "Eberconazole 1% cream is an effective and safe alternative for dermatophytosis treatment: multicenter, randomized, double-blind, comparative trial with miconazole 2% cream".International Journal of Dermatology.45 (5):600–4.doi:10.1111/j.1365-4632.2006.02841.x.PMID 16700802.
^"Eberconazole".Drugs.com. Archived fromthe original on 2021-01-17. Retrieved2017-01-15.

Antifungals (D01 andJ02)

Wall/
membrane

Ergosterol
inhibitors

Azoles (lanosterol 14α-
demethylase inhibitors)

Imidazoles	Topical:bifonazole^‡ butoconazole chlormidazole^‡ climbazole clotrimazole^# croconazole^‡ eberconazole econazole fenticonazole^‡ flutrimazole isoconazole ketoconazole luliconazole miconazole^# neticonazole^‡ omoconazole^‡ oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole
Triazoles	Topical:efinaconazole fluconazole^# terconazole Systemic:fluconazole^# fosfluconazole fosravuconazole hexaconazole^‡ isavuconazole itraconazole^# oteseconazole posaconazole voriconazole^# Unknown:albaconazole^‡ ravuconazole^†
Thiazoles	Topical:abafungin^‡

Polyene antimycotics
(ergosterol binding)

Topical:hamycin^‡
natamycin
nystatin^#
Systemic:amphotericin B^#, hamycin^‡

Squalene monooxygenase
inhibitors

Allylamines	Topical:naftifine terbinafine Systemic: terbinafine
Benzylamines	Topical:butenafine

Others

Topical:amorolfine

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	Systemic:flucytosine^#
Mitotic inhibitors	Systemic:griseofulvin^#
Aminoacyl tRNA synthetase inhibitors	Topical:tavaborole

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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