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EPH receptor A5

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

EPHA5

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2R2P,4ET7

Identifiers

Aliases

EPHA5, CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4, EPH receptor A5

External IDs

OMIM:600004;MGI:99654;HomoloGene:55824;GeneCards:EPHA5;OMA:EPHA5 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.1-q13.2	Start	65,319,563bp^[1]
Band	4q13.1-q13.2	End	65,670,495bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 E1\|5 43.0 cM	Start	84,202,620bp^[2]
Band	5 E1\|5 43.0 cM	End	84,565,241bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

ventricular zone

sperm

prefrontal cortex

middle temporal gyrus

testicle

entorhinal cortex

dorsolateral prefrontal cortex

primary visual cortex

frontal pole

Top expressed in

ganglionic eminence

ventral tegmental area

ventricular zone

Region I of hippocampus proper

substantia nigra

barrel cortex

olfactory bulb

piriform cortex

amygdala

hippocampus proper

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity
Cellular component	integral component of membrane rough endoplasmic reticulum cell projection membrane plasma membrane integral component of plasma membrane axon soma dendrite perinuclear region of cytoplasm external side of plasma membrane cytoplasm neuron projection receptor complex
Biological process	regulation of insulin secretion involved in cellular response to glucose stimulus regulation of actin cytoskeleton organization phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway regulation of GTPase activity neuron development nervous system development protein phosphorylation positive regulation of CREB transcription factor activity peptidyl-tyrosine phosphorylation hippocampus development cAMP-mediated signaling axon guidance ephrin receptor signaling pathway negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2044


13839

Ensembl


ENSG00000145242


ENSMUSG00000029245

UniProt


P54756


Q60629

RefSeq (mRNA)

NM_001281765 NM_001281766 NM_001281767 NM_004439 NM_182472
NM_001318761


NM_007937

RefSeq (protein)

NP_001268694 NP_001268695 NP_001268696 NP_001305690 NP_004430
NP_872272

NP_031963 NP_001389678 NP_001389679 NP_001389680 NP_001389681
NP_001389682 NP_001389683 NP_001389684 NP_001389685 NP_001389686 NP_001389687 NP_001389688 NP_001389689 NP_001389690

Location (UCSC)

Chr 4: 65.32 – 65.67 Mb

Chr 5: 84.2 – 84.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

EPH receptor A5 (ephrin type-A receptor 5) is aprotein that in humans is encoded by theEPHA5gene.^[5]^[6]^[7]

This gene belongs to theephrin receptor subfamily of theprotein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in thenervous system. Receptors in the EPH subfamily typically have a singlekinase domain and an extracellular region containing a Cys-rich domain and 2fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-Bligands.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000145242 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000029245 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ephnomenclaturecommittee (Sep 1997)."Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee".Cell.90 (3):403–4.doi:10.1016/S0092-8674(00)80500-0.PMID 9267020.S2CID 26773768.
^Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995)."A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12".Genomics.22 (2):431–6.doi:10.1006/geno.1994.1405.PMID 7528718.
^^a ^b"Entrez Gene: EPHA5 EPH receptor A5".

Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands".Cell Tissue Res.290 (2):251–9.doi:10.1007/s004410050929.PMID 9321686.S2CID 1506266.
Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1".Cell Tissue Res.290 (2):261–4.doi:10.1007/s004410050930.PMID 9321687.S2CID 39695853.
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development".Annu. Rev. Neurosci.21:309–45.doi:10.1146/annurev.neuro.21.1.309.PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands".Pharmacol. Ther.77 (3):151–81.doi:10.1016/S0163-7258(97)00112-5.PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis".Development.126 (10):2033–44.doi:10.1242/dev.126.10.2033.PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly".Int. Rev. Cytol. International Review of Cytology.196:177–244.doi:10.1016/S0074-7696(00)96005-4.ISBN 9780123646002.PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001)."Roles of Eph receptors and ephrins in segmental patterning".Philos. Trans. R. Soc. Lond. B Biol. Sci.355 (1399):993–1002.doi:10.1098/rstb.2000.0635.PMC 1692797.PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development".Nat. Rev. Neurosci.2 (3):155–64.doi:10.1038/35058515.PMID 11256076.S2CID 205014301.
Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases".Oncogene.10 (5):897–905.PMID 7898931.
Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity".Science.266 (5186):816–9.Bibcode:1994Sci...266..816D.doi:10.1126/science.7973638.PMID 7973638.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996)."Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis".Neuron.17 (1):9–19.doi:10.1016/S0896-6273(00)80276-7.PMID 8755474.S2CID 1075856.
Miescher GC, Taylor V, Olivieri G, et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors".Brain Res. Mol. Brain Res.46 (1–2):17–24.doi:10.1016/S0169-328X(96)00268-9.PMID 9191074.
Stein E, Savaskan NE, Ninnemann O, et al. (1999)."A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting".J. Neurosci.19 (20):8885–93.doi:10.1523/JNEUROSCI.19-20-08885.1999.PMC 6782767.PMID 10516308.

Protein kinases:tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4
Insulin receptor family	IGF1R INSR INSRR
PDGF receptor family	CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB)
FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4
VEGF receptors family	VEGFR1 VEGFR2 VEGFR3
HGF receptor family	MET RON
Trk receptor family	NTRK1 NTRK2 NTRK3

EPH receptor family

LTK receptor family

TIE receptor family

ROR receptor family

DDR receptor family

PTK7 receptor family

PTK7

RYK receptor family

MuSK receptor family

MUSK

ROS receptor family

ROS1

AATYK receptor family

AXL receptor family

RET receptor family

uncategorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 ARG
ACK family	ACK1 TNK1
CSK family	CSK MATK
FAK family	FAK PYK2
FES family	FES FER
FRK family	FRK BRK SRMS
JAK family	JAK1 JAK2 JAK3 TYK2
SRC-A family	SRC FGR FYN YES1
SRC-B family	BLK HCK LCK LYN
TEC family	TEC BMX BTK ITK TXK
SYK family	SYK ZAP70

Growth factor receptor modulators

Angiopoietin

Agonists:Angiopoietin 1
Angiopoietin 4

Antagonists:Angiopoietin 2
Angiopoietin 3

Kinase inhibitors:Altiratinib
CE-245677
Rebastinib

Antibodies:Evinacumab (against angiopoietin 3)
Nesvacumab (against angiopoietin 2)

CNTF

EGF (ErbB)

EGF (ErbB1/HER1)	Agonists:Amphiregulin Betacellulin EGF (urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Murodermin Nepidermin Transforming growth factor alpha (TGFα) Kinase inhibitors:Afatinib Agerafenib Brigatinib Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies:Cetuximab Depatuxizumab Depatuxizumab mafodotin Futuximab Imgatuzumab Matuzumab Necitumumab Nimotuzumab Panitumumab Zalutumumab
ErbB2/HER2	Agonists:Unknown/none Antibodies:Ertumaxomab Pertuzumab Trastuzumab Trastuzumab deruxtecan Trastuzumab duocarmazine Trastuzumab emtansine Kinase inhibitors:Afatinib Lapatinib Mubritinib Neratinib Tucatinib
ErbB3/HER3	Agonists:Neuregulins (heregulins) (1,2,6 (neuroglycan C)) Antibodies:Duligotumab Patritumab Seribantumab
ErbB4/HER4	Agonists:Betacellulin Epigen Heparin-binding EGF-like growth factor (HB-EGF) Neuregulins (heregulins) (1,2,3,4,5 (tomoregulin, TMEFF))

FGF

FGFR1	Agonists:Ersofermin FGF (1,2 (bFGF),3,4,5,6,8,10 (KGF2),20) Repifermin Selpercatinib Trafermin Velafermin
FGFR2	Agonists:Ersofermin FGF (1,2 (bFGF),3,4,5,6,7 (KGF),8,9,10 (KGF2),17,18,22) Palifermin Repifermin Selpercatinib Sprifermin Trafermin Antibodies:Aprutumab Aprutumab ixadotin Kinase inhibitors:Infigratinib
FGFR3	Agonists:Ersofermin FGF (1,2 (bFGF),4,8,9,18,23) Selpercatinib Sprifermin Trafermin Antibodies:Burosumab (against FGF23)
FGFR4	Agonists:Ersofermin FGF (1,2 (bFGF),4,6,8,9,19) Trafermin
Unsorted	Agonists:FGF15/19

HGF (c-Met)

Agonists:Fosgonimeton
Hepatocyte growth factor

Potentiators:Dihexa (PNB-0408)

IGF

IGF-1	Agonists:des(1-3)IGF-1 Insulin-like growth factor-1 (somatomedin C) IGF-1 LR3 Insulin-like growth factor-2 (somatomedin A) Insulin Mecasermin Mecasermin rinfabate Kinase inhibitors:BMS-754807 Linsitinib NVP-ADW742 NVP-AEW541 OSl-906 Antibodies:AVE-1642 Cixutumumab Dalotuzumab Figitumumab Ganitumab Robatumumab R1507 Teprotumumab Xentuzumab (against IGF-1 and IGF-2)
IGF-2	Agonists:Insulin-like growth factor-2 (somatomedin A) Antibodies:Dusigitumab Xentuzumab (against IGF-1 and IGF-2)
Others	Binding proteins:IGFBP (1,2,3,4,5,6,7) Cleavage products/derivatives with unknown target:Glypromate (GPE, (1-3)IGF-1) Trofinetide

LNGF (p75^NTR)

Antibodies:Against NGF:ABT-110 (PG110)
ASP-6294
Fasinumab
Frunevetmab
Fulranumab
MEDI-578
Ranevetmab
Tanezumab

Aptamers:Against NGF:RBM-004

Decoy receptors:LEVI-04 (p75^NTR-Fc)

PDGF

Agonists:Becaplermin
Platelet-derived growth factor (A,B,C,D)

RET (GFL)

GFRα1	Agonists:Glial cell line-derived neurotrophic factor (GDNF) Liatermin Kinase inhibitors:Vandetanib
GFRα2	Agonists:Neurturin (NRTN) Kinase inhibitors:Vandetanib
GFRα3	Agonists:Artemin (ARTN) Kinase inhibitors:Vandetanib
GFRα4	Agonists:Persephin (PSPN) Kinase inhibitors:Vandetanib
Unsorted	Kinase inhibitors:Agerafenib

SCF (c-Kit)

Agonists:Ancestim
Stem cell factor

TGFβ

Seehere instead.

Trk

TrkA	Agonists:Amitriptyline BNN-20 BNN-27 Cenegermin DHEA DHEA-S Gambogic amide NGF Tavilermide Antagonists:ALE-0540 Dexamethasone FX007 Testosterone Negative allosteric modulators:VM-902A Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib Milciclib ONO-4474 ONO-5390556 PLX-7486 Rebastinib SNA-120 (pegylated K252a)) Antibodies:Against TrkA:GBR-900;Against NGF:ABT-110 (PG110) ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers:Against NGF:RBM-004 Decoy receptors:ReN-1820 (TrkAd5)
TrkB	Agonists:3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline BDNF BNN-20 Deoxygedunin Deprenyl Diosmetin DMAQ-B1 HIOC LM22A-4 N-Acetylserotonin NT-3 NT-4 Norwogonin (5,7,8-THF) R7 R13 TDP6 Antagonists:ANA-12 Cyclotraxin B Gossypetin (3,5,7,8,3',4'-HHF) Ligands:DHEA Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486
TrkC	Agonists:BNN-20 DHEA NT-3 Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486