Ephrin type-B receptor 6 is aprotein that in humans is encoded by theEPHB6gene.[5]
Ephrin receptors and theirligands, the ephrins, mediate numerous developmental processes, particularly in thenervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to themembrane by aglycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which aretransmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of thereceptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks thekinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.[5]
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