ETS domain-containing protein Elk-3 is aprotein that in humans is encoded by theELK3gene.[5][6]
The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively".Genomics.23 (3):710–1.doi:10.1006/geno.1994.1564.PMID7851904.
Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family".Int. J. Biochem. Cell Biol.29 (12):1371–87.doi:10.1016/S1357-2725(97)00086-1.PMID9570133.
Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway".Trends Biochem. Sci.23 (6):213–6.doi:10.1016/S0968-0004(98)01211-0.PMID9644975.
