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EIF2AK4

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

EIF2AK4

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1UKX,4OTN

Identifiers

Aliases

EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4

External IDs

OMIM:609280;MGI:1353427;HomoloGene:40891;GeneCards:EIF2AK4;OMA:EIF2AK4 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q15.1	Start	39,934,115bp^[1]
Band	15q15.1	End	40,035,591bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 E5	Start	118,219,099bp^[2]
Band	2\|2 E5	End	118,305,715bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

anterior pituitary

bone marrow cells

stromal cell of endometrium

synovial membrane

tibia

Achilles tendon

Brodmann area 9

nucleus accumbens

left uterine tube

caudate nucleus

Top expressed in

medullary collecting duct

secondary oocyte

primary oocyte

zygote

saccule

otic placode

Paneth cell

external carotid artery

epithelium of lens

internal carotid artery

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity tRNA binding kinase activity protein serine/threonine kinase activity RNA binding ATP binding eukaryotic translation initiation factor 2alpha kinase activity
Cellular component	cytoplasm polysome cytosolic ribosome
Biological process	positive regulation of translational initiation in response to starvation adaptive immune response negative regulation of neuron differentiation positive regulation of long-term synaptic potentiation positive regulation of adaptive immune response negative regulation of translational initiation in response to stress negative regulation of translational initiation phosphorylation immune system process cellular response to UV cellular response to amino acid starvation negative regulation of CREB transcription factor activity regulation of feeding behavior learning nervous system development viral translation neuron projection extension protein phosphorylation cellular response to cold long-term memory defense response to virus cellular response to leucine starvation eiF2alpha phosphorylation in response to endoplasmic reticulum stress induction by virus of host autophagy protein autophosphorylation cell cycle negative regulation by host of viral genome replication viral process regulation of translation regulation of translational initiation positive regulation of defense response to virus by host T cell activation involved in immune response DNA damage checkpoint signaling regulation of translational initiation by eIF2 alpha phosphorylation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


440275


27103

Ensembl


ENSG00000128829


ENSMUSG00000005102

UniProt


Q9P2K8


Q9QZ05

RefSeq (mRNA)


NM_001013703


NM_001177806 NM_013719 NM_001355383

RefSeq (protein)


NP_001013725


NP_001171277 NP_038747 NP_001342312

Location (UCSC)

Chr 15: 39.93 – 40.04 Mb

Chr 2: 118.22 – 118.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 4 is anenzyme that in humans is encoded by theEIF2AK4gene.^[5]^[6]

EIF2AK4 belongs to a family of kinases thatphosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulateprotein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000128829 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000005102 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Berlanga JJ, Santoyo J, De Haro C (Nov 1999)."Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase".Eur J Biochem.265 (2):754–62.doi:10.1046/j.1432-1327.1999.00780.x.PMID 10504407.
^^a ^b"Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:Q9P2K8 (eIF-2-alpha kinase GCN2) at thePDBe-KB.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)