Eukaryotic translation initiation factor 2-alpha kinase 3, also known asprotein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is anenzyme that in humans is encoded by theEIF2AK3gene.[5][6][7][8]
The protein encoded by this genephosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in theendoplasmic reticulum (ER), where it is induced by ER stress caused bymalfolded proteins.[6]
^Hayes SE, Conner LJ, Stramm LE, Shi Y (1999). "Assignment of pancreatic eIF-2alpha kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization".Cytogenetics and Cell Genetics.86 (3–4):327–328.doi:10.1159/000015328.PMID10575235.S2CID84483593.
^Søvik O, Njølstad PR, Jellum E, Molven A (December 2008). "Wolcott-Rallison syndrome with 3-hydroxydicarboxylic aciduria and lethal outcome".Journal of Inherited Metabolic Disease.31 (Suppl 2):S293–S297.doi:10.1007/s10545-008-0866-1.PMID18500571.S2CID1751676.
^Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (June 2000). "Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response".Nature Cell Biology.2 (6):326–332.doi:10.1038/35014014.PMID10854322.S2CID22684712.
Delépine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C (August 2000). "EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome".Nature Genetics.25 (4):406–409.doi:10.1038/78085.PMID10932183.S2CID24521894.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".Nature Biotechnology.22 (6):707–716.doi:10.1038/nbt971.PMID15146197.S2CID27764390.
Allotey RA, Mohan V, McDermott MF, Deepa R, Premalatha G, Hassan Z, et al. (December 2004). "The EIF2AK3 gene region and type I diabetes in subjects from South India".Genes and Immunity.5 (8):648–652.doi:10.1038/sj.gene.6364139.PMID15483661.S2CID21566833.
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