Egl nine homolog 2 is aprotein that in humans is encoded by theEGLN2gene.[5] ELGN2 is analpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins.
Thehypoxia inducible factor (HIF) is a transcriptional complex which is involved inoxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation byprolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[5]
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