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EG-018

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
EG-018
Legal status
Legal status
Identifiers
  • Naphthalen-1-yl-(9-pentylcarbazol-3-yl)methanone
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC28H25NO
Molar mass391.514 g·mol−1
3D model (JSmol)
  • CCCCCN1C2=C(C=C(C=C2)C(=O)C3=CC=CC4=CC=CC=C43)C5=CC=CC=C51
  • InChI=1S/C28H25NO/c1-2-3-8-18-29-26-15-7-6-13-23(26)25-19-21(16-17-27(25)29)28(30)24-14-9-11-20-10-4-5-12-22(20)24/h4-7,9-17,19H,2-3,8,18H2,1H3
  • Key:FJMMDJDPNLZYLA-UHFFFAOYSA-N

EG-018 is acarbazole-basedsynthetic cannabinoid that has been sold online as adesigner drug.[1][2][3][4][5] It acts as apartial agonist of theCB1 andCB2 receptor, with reasonably high binding affinity, but low efficacy in terms of inducing a signaling response.[6]

Legal status

[edit]

EG-018 is a controlled substance in Japan.[7]

See also

[edit]

References

[edit]
  1. ^"EG 018".www.caymanchem.com.
  2. ^Mogler L, Franz F, Wilde M, Huppertz LM, Halter S, Angerer V, et al. (September 2018). "Phase I metabolism of the carbazole-derived synthetic cannabinoids EG-018, EG-2201, and MDMB-CHMCZCA and detection in human urine samples".Drug Testing and Analysis.10 (9):1417–1429.doi:10.1002/dta.2398.PMID 29726116.
  3. ^Banister SD, Connor M (August 2018). "The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution".New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. Springer International Publishing. pp. 191–226.doi:10.1007/164_2018_144.ISBN 978-3-030-10561-7.PMID 30105473 – via Springer Link.
  4. ^Gaunitz F, Dahm P, Mogler L, Thomas A, Thevis M, Mercer-Chalmers-Bender K (June 2019). "In vitro metabolic profiling of synthetic cannabinoids by pooled human liver microsomes, cytochrome P450 isoenzymes, and Cunninghamella elegans and their detection in urine samples".Analytical and Bioanalytical Chemistry.411 (16):3561–3579.doi:10.1007/s00216-019-01837-8.PMID 31183523.S2CID 184487406.
  5. ^Diao X, Carlier J, Zhu M, Huestis MA (July 2018). "Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry".Forensic Toxicology.36 (2):304–312.doi:10.1007/s11419-018-0404-2.ISSN 1860-8973.S2CID 44196013.
  6. ^Gamage TF, Barrus DG, Kevin RC, Finlay DB, Lefever TW, Patel PR, et al. (June 2020)."In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018".Pharmacology, Biochemistry, and Behavior.193 172918.doi:10.1016/j.pbb.2020.172918.PMC 7239729.PMID 32247816.
  7. ^"指定薬物を指定する省令が公布されました｜厚生労働省".www.mhlw.go.jp (in Japanese). Ministry of Health, Labour and Welfare.
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