Endothelin 1 (ET-1), also known aspreproendothelin-1 (PPET1), is a potentvasoconstrictorpeptide produced by vascularendothelial cells,[5] as well as by cells in the heart (affecting contractility) and kidney (affecting sodium handling).[6] The protein encoded by this gene –EDN1 – isproteolytically processed to release endothelin 1. Endothelin 1 is one of threeisoforms of humanendothelin.
Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[5][7]
Patients with salt-sensitivehypertension have higher plasma ET-1.[6]Endothelin-1 receptor antagonists (Bosentan) are used in the treatment ofpulmonary hypertension.[5] Use of these antagonists prevents pulmonary arterial constriction and thus inhibits pulmonary hypertension.[5]
As of 2020, the role of endothelin-1 in affectinglipid metabolism andinsulin resistance inobesity mechanisms was underclinical research.[8]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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