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EDIL3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

EDIL3

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
4D90

Identifiers

Aliases

EDIL3, DEL1, EGF like repeats and discoidin domains 3

External IDs

OMIM:606018;MGI:1329025;HomoloGene:21166;GeneCards:EDIL3;OMA:EDIL3 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q14.3	Start	83,940,554bp^[1]
Band	5q14.3	End	84,384,880bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 C3	Start	88,969,591bp^[2]
Band	13\|13 C3	End	89,471,342bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

external globus pallidus

inferior ganglion of vagus nerve

pars reticulata

subthalamic nucleus

tibia

pars compacta

superior vestibular nucleus

Pons

lateral nuclear group of thalamus

ventral tegmental area

Top expressed in

lateral geniculate nucleus

medial geniculate nucleus

medial dorsal nucleus

anterior horn of spinal cord

globus pallidus

calvaria

deep cerebellar nuclei

ventral tegmental area

lateral hypothalamus

suprachiasmatic nucleus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium ion binding integrin binding metal ion binding extracellular matrix structural constituent
Cellular component	extracellular vesicle extracellular region extracellular exosome extracellular matrix collagen-containing extracellular matrix
Biological process	multicellular organism development cell adhesion positive regulation of cell-substrate adhesion
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


10085


13612

Ensembl


ENSG00000164176


ENSMUSG00000034488

UniProt


O43854


O35474

RefSeq (mRNA)


NM_001278642 NM_005711


NM_001037987 NM_010103

RefSeq (protein)


NP_001265571 NP_005702


NP_001033076 NP_034233

Location (UCSC)

Chr 5: 83.94 – 84.38 Mb

Chr 13: 88.97 – 89.47 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

EGF like repeats and discoidin domains 3 is aprotein that in humans is encoded by the EDIL3gene.^[5]

Function

[edit]

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000164176 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000034488 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: EGF like repeats and discoidin domains 3". Retrieved2017-07-24.

Rezaee M, Penta K, Quertermous T (2002). "Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)".Am. J. Physiol. Heart Circ. Physiol.282 (5): H1924–32.doi:10.1152/ajpheart.00921.2001.PMID 11959660.
Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T (2002). "The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation".Microvascular Research.64 (1):148–61.doi:10.1006/mvre.2002.2414.PMID 12074641.
Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion".Eur. J. Cancer Prev.16 (6):517–27.doi:10.1097/CEJ.0b013e3280145c00.PMID 18090124.S2CID 1825380.
Zou X, Qiao H, Jiang X, Dong X, Jiang H, Sun X (2009)."Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer".J. Biomed. Sci.16 (1): 33.doi:10.1186/1423-0127-16-33.PMC 2666667.PMID 19292890.
Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK (2009)."The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations".Hum. Genet.126 (5):655–66.doi:10.1007/s00439-009-0714-x.PMC 2783187.PMID 19578876.
Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB (2010)."Chemerin, a novel adipokine in the regulation of angiogenesis".J. Clin. Endocrinol. Metab.95 (5):2476–85.doi:10.1210/jc.2010-0042.PMC 2869547.PMID 20237162.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010)."Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score".Mol. Med.16 (7–8):247–53.doi:10.2119/molmed.2009.00159.PMC 2896464.PMID 20379614.
Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (2010)."High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients".World J. Gastroenterol.16 (36):4611–5.doi:10.3748/wjg.v16.i36.4611.PMC 2945496.PMID 20857535.
Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF (2010)."A genome-wide study reveals copy number variants exclusive to childhood obesity cases".Am. J. Hum. Genet.87 (5):661–6.doi:10.1016/j.ajhg.2010.09.014.PMC 2978976.PMID 20950786.

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