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EBF1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

EBF1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3LYR,3MQI

Identifiers

Aliases

EBF1, COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1

External IDs

OMIM:164343;MGI:95275;HomoloGene:7297;GeneCards:EBF1;OMA:EBF1 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q33.3	Start	158,695,916bp^[1]
Band	5q33.3	End	159,099,916bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 B1.1\|11 26.45 cM	Start	44,617,317bp^[2]
Band	11 B1.1\|11 26.45 cM	End	45,008,091bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

synovial joint

synovial membrane

Achilles tendon

oocyte

buccal mucosa cell

skin of hip

cardiac muscle tissue of right atrium

parietal pleura

vena cava

spinal ganglia

Top expressed in

external carotid artery

internal carotid artery

trigeminal ganglion

superior cervical ganglion

spinal ganglia

neural tube

ankle

lumbar spinal ganglion

subcutaneous adipose tissue

brown adipose tissue

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding protein binding metal ion binding DNA-binding transcription factor activity protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific C2H2 zinc finger domain binding DNA-binding transcription activator activity, RNA polymerase II-specific
Cellular component	nucleus
Biological process	multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


1879


13591

Ensembl


ENSG00000164330


ENSMUSG00000057098

UniProt


Q9UH73


Q07802

RefSeq (mRNA)

NM_001290360 NM_024007 NM_182708 NM_001324101 NM_001324103
NM_001324106 NM_001324107 NM_001324108 NM_001324109 NM_001324111 NM_001364155 NM_001364156 NM_001364157 NM_001364158 NM_001364159


NM_001290709 NM_001290710 NM_001290711 NM_007897

RefSeq (protein)

NP_001277289 NP_001311030 NP_001311032 NP_001311035 NP_001311036
NP_001311037 NP_001311038 NP_001311040 NP_076870 NP_874367 NP_001351084 NP_001351085 NP_001351086 NP_001351087 NP_001351088

NP_001277638 NP_001277639 NP_001277640 NP_031923 NP_001349498
NP_001349500 NP_001349503 NP_001349504 NP_001349505 NP_001349506 NP_001349507 NP_001349508

Location (UCSC)

Chr 5: 158.7 – 159.1 Mb

Chr 11: 44.62 – 45.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transcription factor COE1 is aprotein that in humans is encoded by theEBF1gene. EBF1 stands forEarly B-Cell Factor 1.^[5]^[6]^[7]

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.^[8]^[9] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.^[10] In addition, EBF1 is also noted for its role inchondrogenic differentiation in limb budmesenchymal progenitor cells.^[11]

Interactions

[edit]

EBF1 has been shown tointeract withZNF423^[12] andCREB binding protein.^[13]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000164330 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000057098 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Symbol Report: EBF1".HUGO Gene Nomenclature Committee. Archived fromthe original on 2018-01-03. Retrieved2018-03-23.
^Milatovich A, Qiu RG, Grosschedl R, Francke U (April 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11".Mammalian Genome.5 (4):211–215.doi:10.1007/BF00360547.PMID 8012110.S2CID 19839522.
^"Entrez Gene: EBF1 early B-cell factor 1".
^Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, et al. (May 2010)."Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin".Immunity.32 (5):714–725.doi:10.1016/j.immuni.2010.04.013.PMID 20451411.
^Hagman J, Ramírez J, Lukin K (January 2012). "B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1". In Murre C (ed.).Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology. Vol. 356. pp. 17–38.doi:10.1007/82_2011_139.ISBN 978-3-642-24102-4.ISSN 0070-217X.PMC 3925327.PMID 21735360.
^Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, et al. (October 2016). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells".Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.1859 (10):1259–1268.doi:10.1016/j.bbagrm.2016.07.004.PMID 27424222.
^Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, et al. (May 2023)."The temporal transcriptomic signature of cartilage formation".Nucleic Acids Research.51 (8):3590–3617.doi:10.1093/nar/gkad210.PMC 10164575.PMID 36987858.
^Tsai RY, Reed RR (June 1997)."Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development".The Journal of Neuroscience.17 (11):4159–4169.doi:10.1523/JNEUROSCI.17-11-04159.1997.PMC 6573535.PMID 9151733.
^Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (June 2003)."Inhibition of p300/CBP by early B-cell factor".Molecular and Cellular Biology.23 (11):3837–3846.doi:10.1128/MCB.23.11.3837-3846.2003.PMC 155219.PMID 12748286.

External links

[edit]

FactorBook EBF1

This article on agene on humanchromosome 5 is astub. You can help Wikipedia byadding missing information.

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	DEC 1 2 BHLHA9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

Retrieved from "https://en.wikipedia.org/w/index.php?title=EBF1&oldid=1301092711"

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References

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External links