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Excitatory amino acid transporter 4

From Wikipedia, the free encyclopedia
(Redirected fromEAAT4)
Protein found in humans

SLC1A6
Identifiers
AliasesSLC1A6, EAAT4, solute carrier family 1 member 6
External IDsOMIM:600637;MGI:1096331;HomoloGene:21055;GeneCards:SLC1A6;OMA:SLC1A6 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SLC1A6
Genomic location for SLC1A6
Band19p13.12Start14,950,033bp[1]
End15,022,990bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SLC1A6
Genomic location for SLC1A6
Band10 C1|10 39.72 cMStart78,616,330bp[2]
End78,650,599bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • endothelial cell

  • left testis

  • right testis

  • paraflocculus of cerebellum

  • skin of thigh

  • cerebellar vermis

  • nucleus accumbens

  • oocyte

  • caudate nucleus
Top expressed in
  • cerebellar vermis

  • lobe of cerebellum

  • dorsomedial hypothalamic nucleus

  • lumbar subsegment of spinal cord

  • ventromedial nucleus

  • inferior colliculi

  • superior colliculus

  • dentate gyrus of hippocampal formation granule cell

  • lateral hypothalamus

  • ventral tegmental area
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6511

20513

Ensembl

ENSG00000105143

ENSMUSG00000005357

UniProt

P48664

O35544

RefSeq (mRNA)
NM_001272087
NM_001272088
NM_005071
NM_001384669
NM_001384670

NM_001384671

NM_009200

RefSeq (protein)

NP_001259016
NP_001259017
NP_005062

NP_033226

Location (UCSC)Chr 19: 14.95 – 15.02 MbChr 10: 78.62 – 78.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Excitatory amino-acid transporter 4 (EAAT4) is aprotein that in humans is encoded by theSLC1A6gene.[5][6]

EAAT4 is expressed predominantly in thecerebellum, has high affinity for theexcitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000105143 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000005357 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
  6. ^abFairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel".Nature.375 (6532):599–603.Bibcode:1995Natur.375..599F.doi:10.1038/375599a0.PMID 7791878.S2CID 4334983.

Further reading

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
ASTTooltip Aspartate aminotransferase
ALTTooltip Alanine aminotransferase
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase


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