Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

EA-1356

From Wikipedia, the free encyclopedia
EA-1356
Names
Preferred IUPAC name
2-Methylcyclohexyl methylphosphonofluoridate
Other names
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C8H16FO2P/c1-7-5-3-4-6-8(7)11-12(2,9)10/h7-8H,3-6H2,1-2H3
    Key: YBZCCTLVJWWETH-UHFFFAOYSA-N
  • CC1CCCCC1OP(=O)(C)F
Properties
C8H16FO2P
Molar mass194.186 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

EA-1356 is a G-seriesorganophosphatenerve agent closely related tosarin.[2][3] It is highly resistant to enzymatic degradation in the body.[4] The nerve agent was tested at Edgewood Arsenal in Maryland (the "EA" in "EA-1356") among many other chemicals tested on humans. A novel enzyme was patented by the US Army in 2018 to break downEA-1356. It is aschedule 1 substance within theChemical Weapons Convention. It is under the category of munitions of ML7.b.1.a.

References

[edit]
  1. ^Noga, M.; Michalska, A.; Jurowski, K. (2024). "The estimation of acute oral toxicity (LD(50)) of G-series organophosphorus-based chemical warfare agents using quantitative and qualitative toxicology in silico methods".Archives of Toxicology.98 (6):1809–1825.doi:10.1007/s00204-024-03714-5.PMID 38493428.
  2. ^Söderström MT, Ketola RA, Kostiainen O (1995). "Identification of some nerve agent homologues and dialkyl methylphosphonates by gas chromatography/Fourier transform infrared spectrometry".Fresenius' Journal of Analytical Chemistry.352 (6):550–556.doi:10.1007/BF00323072.S2CID 100910978.
  3. ^Ellison DH (2008).Handbook of Chemical and Biological Warfare Agents (Second ed.). CRC Press.ISBN 978-0-849-31434-6.
  4. ^US 10124043, Harvey SP, Guelta MA, McMahon LR, "Mutant OPAA enzymes with increased catalytic efficiency on organophosphorus compound EA1356", issued 13 November 2018, assigned to U.S. Army Edgewood Chemical Biological Center 
Blood agents
Blister agents
Arsenicals
Sulfur mustards
Nitrogen mustards
Nettle agents
Other
Nerve agents
G-agents
V-agents
GV agents
Novichok agents
Carbamates
Other
Precursors
Neurotoxins
Pulmonary/
choking agents
Vomiting agents
Incapacitating
agents
Lachrymatory
agents
Malodorant agents
Cornea-clouding agents
Biological toxins
Tumor promoting agents
Other
Animal toxins
Bacterial
Cyanotoxins
Plant toxins
Mycotoxins
Pesticides
Nerve agents
Bicyclic phosphates
Cholinergic neurotoxins
Psychoactive drugs
Other
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers
Stub icon

This article about anorganic compound is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=EA-1356&oldid=1301051470"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp