| Combination of | |
|---|---|
| Hydrochlorothiazide | Thiazidediuretic |
| Triamterene | Potassium-sparing diuretic |
| Clinical data | |
| Trade names | Dyazide, Maxzide, others |
| Other names | co-triamterzide |
| AHFS/Drugs.com | Professional Drug Facts |
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| Routes of administration | By mouth |
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Hydrochlorothiazide/triamterene, also known asco-triamterzide, is afixed-dose combination medication ofhydrochlorothiazide andtriamterene.[1][2][3] It is used to treathigh blood pressure andedema (swelling).[1][2][3] Specifically it is used in those who developlow blood potassium (hypokalemia) when on only hydrochlorothiazide.[1][2] It is takenby mouth.[1][2][3]
Side effects may include nausea, trouble sleeping, dizziness,feeling light headed with standing, kidney problems,allergies, and muscle cramps.[1][2] Other serious side effects may includehigh blood potassium.[1][2] Use inpregnancy andbreastfeeding is not generally recommended.[1][2] Use in those with significant kidney problems is not recommended.[1][2] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[1][2]
The combination was approved for medical use in the United States in 1965.[4] In 2023, it was the 115th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[5][6]
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