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Octavian Bucur is aRomanian-American scientist and the General Director of the Genomics Research and Development Institute (ICDG) in Bucharest, Romania.[1][2] He is also an Associate Investigator at the Viron Molecular Medicine Institute in Boston, MA, USA[3] and serves as the Romanian Representative to the 1+ Million Genomes European initiative (1+MG).[2]
Bucur was born in Craiova, Romania in theOltenia region. During secondary school, he participated in national competitions in physics, and biology, including the Romanian National Olympiad of Physics (11th grade) and the National Olympiad of Biology (12th grade). Following an award at the National Biology Olympiad (Genetics),[4] he received a scholarship to attend a university of his choice in Romania.[5] In 1999, Bucur enrolled in theCarol Davila University of Medicine and Pharmacy in Bucharest. As a medical student, he collaborated with Drs. Mircea Leabu and Roxana Nat, publishing his first original scientific paper as the first author during his studies.[6]
After receiving his M.D. degree, Bucur began a research fellowship atHarvard University and later completed a PhD in Biology/Biochemistry at the Romanian Academy - Institute of Biochemistry, where he graduated with the highest distinction. His doctoral research was conducted at the Beth Israel Deaconess Medical Center (BIDMC),Harvard Medical School, under supervision of Professors Stefana Petrescu, Roya Khosravi-Far and Prof. Alex Almasan. He subsequently trained as a postdoctoral fellow at the BIDMC, Harvard Medical School under Prof. Andrew H. Beck, focusing on molecular, digital, and computational pathology, with an emphasis on biomedical technology development and artificial intelligence (AI) applications in pathology. In 2027, he obtained a Certificate in Applied Biostatistics from the Harvard Clinical and Translational Science Center.[2][3][4][5][6][7]
Over the following few years, Bucur held multiple academic and research appointments at Harvard University, including:
In October 2023, Bucur was elected as the General Director of theGenomics Research and Development Institute (ICDG) in Bucharest for a period of 3 years. Bucur has served as Romania's representative to the European 1+ Million Genomes Initiative from 2023 and the European Infrastructure for Drug Repurposing (RePo4EU) from 2024. He was appointed as a Honorary Scientific Advisor to the Rector of the Carol Davila University of Medicine and Pharmacy, Prof. Viorel Jinga in 2023.[1][2]
His professional background includes positions in academic institutions, research organizations, and biotechnology companies. He co-founded Viron Therapeutics LLC (now Porosome Therapeutics) in Boston, Massachusetts,[8] where he served as Chief Executive Officer. Bucur is also co-Founder and Editor-in-Chief ofDiscoveries, a peer-reviewed biomedical journal indexed in PubMed and PubMedCentral (PMC), together with Prof. Elisa A. Liehn.[9]
Bucur's research has focused on molecular pathology, molecular oncology, spatial genomics, and biomedical technology development. Together with his collaborators from Harvard University and MIT, including Yongxin Zhao, Edward Boyden, and Andrew Beck, he is a main contributor to the development of Expansion Pathology, a method published inNature Biotechnology (2017) andNature Protocols (2020).[6][7][8][9][10] The method involves the physical expansion of fixed tissue samples for improved pathology diagnostics, improving the resolution of conventional optical microscopy and enabling nanoscale imaging using standard equipment. Related technologies have been described in the context of pathology, spatial genomics, neuroscience, and molecular medicine.'[10][11][12][13][14][15][16]'
At the Wyss Institute for Biologically Inspired Engineering at Harvard, Bucur collaborated in projects related to Fluorescence in Situ Sequencing (FISSEQ), a spatial genomics technique with applications in genomics and molecular biology.[2][3]
As General Director of ICDG, Bucur has overseen the institute's development, including securing of and participation in several European genomic projects, including Genomic Data Infrastructure (GDI), Genome of Europe, Beyond 1 Million Genomes Plus (B1MG Plus) and EU4Health Joint Action - Personalized Cancer Medicine (JA PCM).[2][3][6] Within the ROGEN project, initiated in December 2024, ICDG has the highest budget of approximately €18 million to develop the Romanian national infrastructure for sequencing, genomics, and computational genomics research, the genomic research in Romania and to define the Romanian Reference Genome and perform studies of the diversity of Romanian population.[17][18]
Bucur has received numerous awards related to biomedical research and academic activity[2][3], including:
In Romania, he received theTop Romanian Young Scientist Award (2023) from the Romanian Ministry of Research, Innovation, and Digitalization, during the Romanian Research Gala,[19] as well as theCarol Davila Award for Accomplishment in Medicine (2023), presented by the Romanian Academy and MLNR.[20]
Category:Romanian physiciansCategory:Romanian scientistsCategory:Genomics