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Draft:Octavian Bucur

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    Declined byScope creep 16 days ago. Last edited byScope creep 16 days ago. Reviewer:Inform author.
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    Submission declined on 23 October 2025 byPythoncoder (talk).
    This submission does not appear to be written inthe formal tone expected of an encyclopedia article. Entries should be written from aneutral point of view, and should refer to a range ofindependent, reliable, published sources. Please rewrite your submission in a more encyclopedic format. Please make sure to avoidpeacock terms that promote the subject.
    Declined byPythoncoder 3 months ago.
    • Comment: There is no dates either. Put month/year date in. Hope that helps.scope_creepTalk 18:45, 1 February 2026 (UTC)
    • Comment: Please remove the patents. There are non-rs. No patent references on Wikipedia. I took out the Youtube vids. The guy is notable and doesn't need them. Please take a look atWP:REFB, a small tutorial to shows you how to do references. Ping me when your done.scope_creepTalk 18:44, 1 February 2026 (UTC)
    • Comment: Before you submit this for review please:
      * Read and apply what you learn inWP:REFB andWP:CITE
      * do the same withMOS:HEAD
      * All inline links should be removed, please, and turned into references if appropriate, Wikilinks, or external links in a section so named. SeeWikipedia:External links. There should be no links pointing to external sources until those in the 'References' section (with the exception of one optional link in any infobox).
      * NoteWP:NPROF and make sure your references verify that the criteria are passed
      There will be more to do, but these are the basics 🇵🇸‍🇺🇦 FiddleTimtrent FaddleTalk to me 🇺🇦‍🇵🇸 21:51, 22 October 2025 (UTC)

    Romanian-American genomics researcher (born 1970s)

    Octavian Bucur is aRomanian-American scientist and the General Director of the Genomics Research and Development Institute (ICDG) in Bucharest, Romania.[1][2] He is also an Associate Investigator at the Viron Molecular Medicine Institute in Boston, MA, USA[3] and serves as the Romanian Representative to the 1+ Million Genomes European initiative (1+MG).[2]

    Early life and education

    [edit]

    Bucur was born in Craiova, Romania in theOltenia region. During secondary school, he participated in national competitions in physics, and biology, including the Romanian National Olympiad of Physics (11th grade) and the National Olympiad of Biology (12th grade). Following an award at the National Biology Olympiad (Genetics),[4] he received a scholarship to attend a university of his choice in Romania.[5] In 1999, Bucur enrolled in theCarol Davila University of Medicine and Pharmacy in Bucharest. As a medical student, he collaborated with Drs. Mircea Leabu and Roxana Nat, publishing his first original scientific paper as the first author during his studies.[6]

    After receiving his M.D. degree, Bucur began a research fellowship atHarvard University and later completed a PhD in Biology/Biochemistry at the Romanian Academy - Institute of Biochemistry, where he graduated with the highest distinction. His doctoral research was conducted at the Beth Israel Deaconess Medical Center (BIDMC),Harvard Medical School, under supervision of Professors Stefana Petrescu, Roya Khosravi-Far and Prof. Alex Almasan. He subsequently trained as a postdoctoral fellow at the BIDMC, Harvard Medical School under Prof. Andrew H. Beck, focusing on molecular, digital, and computational pathology, with an emphasis on biomedical technology development and artificial intelligence (AI) applications in pathology. In 2027, he obtained a Certificate in Applied Biostatistics from the Harvard Clinical and Translational Science Center.[2][3][4][5][6][7]

    Over the following few years, Bucur held multiple academic and research appointments at Harvard University, including:

    Academic and professional Career

    [edit]

    In October 2023, Bucur was elected as the General Director of theGenomics Research and Development Institute (ICDG) in Bucharest for a period of 3 years. Bucur has served as Romania's representative to the European 1+ Million Genomes Initiative from 2023 and the European Infrastructure for Drug Repurposing (RePo4EU) from 2024. He was appointed as a Honorary Scientific Advisor to the Rector of the Carol Davila University of Medicine and Pharmacy, Prof. Viorel Jinga in 2023.[1][2]

    His professional background includes positions in academic institutions, research organizations, and biotechnology companies. He co-founded Viron Therapeutics LLC (now Porosome Therapeutics) in Boston, Massachusetts,[8] where he served as Chief Executive Officer. Bucur is also co-Founder and Editor-in-Chief ofDiscoveries, a peer-reviewed biomedical journal indexed in PubMed and PubMedCentral (PMC), together with Prof. Elisa A. Liehn.[9]

    Research

    [edit]

    Bucur's research has focused on molecular pathology, molecular oncology, spatial genomics, and biomedical technology development. Together with his collaborators from Harvard University and MIT, including Yongxin Zhao, Edward Boyden, and Andrew Beck, he is a main contributor to the development of Expansion Pathology, a method published inNature Biotechnology (2017) andNature Protocols (2020).[6][7][8][9][10] The method involves the physical expansion of fixed tissue samples for improved pathology diagnostics, improving the resolution of conventional optical microscopy and enabling nanoscale imaging using standard equipment. Related technologies have been described in the context of pathology, spatial genomics, neuroscience, and molecular medicine.'[10][11][12][13][14][15][16]'

    At the Wyss Institute for Biologically Inspired Engineering at Harvard, Bucur collaborated in projects related to Fluorescence in Situ Sequencing (FISSEQ), a spatial genomics technique with applications in genomics and molecular biology.[2][3]

    As General Director of ICDG, Bucur has overseen the institute's development, including securing of and participation in several European genomic projects, including Genomic Data Infrastructure (GDI), Genome of Europe, Beyond 1 Million Genomes Plus (B1MG Plus) and EU4Health Joint Action - Personalized Cancer Medicine (JA PCM).[2][3][6] Within the ROGEN project, initiated in December 2024, ICDG has the highest budget of  approximately €18 million to develop the Romanian national infrastructure for sequencing, genomics, and computational genomics research, the genomic research in Romania and to define the Romanian Reference Genome and perform studies of the diversity of Romanian population.[17][18]

    Honors and awards

    [edit]

    Bucur has received numerous awards related to biomedical research and academic activity[2][3], including:

    • Recognition of Outstanding Achievement in Translational and Basic Science Research, Harvard Medical School, Department of Pathology (2017)[citation needed]
    • 10 Years of Pathology Research Award, Beth Israel Deaconess Medical Center (2017)
    • Finalist,Harvard Medical PD Elevator Pitch Competition (2018)
    • AACR–Millennium Pharmaceuticals Award, American Association for Cancer Research (2015)
    • Lady Tata Memorial Trust International Award for Leukemia Research (2007–2008)
    • AACR–Aflac Award, American Association for Cancer Research (2008)
    • Leonardo da Vinci Research Fellowship, European Union (2004)
    • IUBMB Travel Fellowship, Melbourne, Australia (2010)
    • Romanian Government Research Fellowship (2003–2004)

    In Romania, he received theTop Romanian Young Scientist Award (2023) from the Romanian Ministry of Research, Innovation, and Digitalization, during the Romanian Research Gala,[19] as well as theCarol Davila Award for Accomplishment in Medicine (2023), presented by the Romanian Academy and MLNR.[20]

    References

    [edit]
    1. ^ab"Genomics Research and Development Institute - Directors".
    2. ^abcdefgh"Dr. Octavian Bucur - Genomics Research and Development Institute".[dead link]
    3. ^abcdef"Octavian Bucur - Viron Molecular Medicine Institute".
    4. ^ab"Beyond Black and White with Dr. Octavian Bucur (@TVR1)".
    5. ^ab"Interview on the TV show "A second Romania" with Dr. Octavian Bucur (@TVRi)".
    6. ^abcd"Interview on the TV show "A doctor for you - the return that heals"".
    7. ^ab"Radio Romania interview on medical genomics".
    8. ^ab"Porosome Therapeutics former "Viron Therapeutics"".
    9. ^ab"Discoveries journal".
    10. ^abZhao, Y.; Bucur, O.; Irshad, H.; Chen, F.; Weins, A.; Stancu, A. L.; Oh, E. Y.; Distasio, M.; Torous, V.; Glass, B.; Stillman, I. E.; Schnitt, S. J.; Beck, A. H.; Boyden, E. S. (2017)."Zhao Y, Bucur O, Irshad H, Chen F, Weins A, Stancu AL, Oh EY, DiStasio M, Torous V, Glass B, Stillman IE, Schnitt SJ, Beck AH, Boyden ES. Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy. Nat Biotechnol. 2017 Aug;35(8):757-764. doi: 10.1038/nbt.3892. Epub 2017 Jul 17. PMID: 28714966; PMCID: PMC5548617".Nature Biotechnology.35 (8):757–764.doi:10.1038/nbt.3892.PMC 5548617.PMID 28714966.
    11. ^Bucur, O.; Fu, F.; Calderon, M.; Mylvaganam, G. H.; Ly, N. L.; Day, J.; Watkin, S.; Walker, B. D.; Boyden, E. S.; Zhao, Y. (2020)."Bucur O, Fu F, Calderon M, Mylvaganam GH, Ly NL, Day J, Watkin S, Walker BD, Boyden ES, Zhao Y. Nanoscale imaging of clinical specimens using conventional and rapid-expansion pathology. Nat Protoc. 2020 May;15(5):1649-1672. doi: 10.1038/s41596-020-0300-1. Epub 2020 Apr 1. PMID: 32238952; PMCID: PMC7490752".Nature Protocols.15 (5):1649–1672.doi:10.1038/s41596-020-0300-1.PMC 7490752.PMID 32238952.
    12. ^"Patent "Methods for Diagnosing Neoplastic Lesions", WO US US20200041514A1; Inventos: Edward Stuart Boyden, Andrew Hanno Beck, Yongxin Zhao, Octavian Bucur, Humayun Irshad; Current Assignees: Beth Israel Deaconess Medical Center Inc Massachusetts Institute of Technology; Priority 2017-02-24 • Filed 2019-08-15 • Published 2020-02-06".
    13. ^"Patent "Methods for Expanding Clinical Tissue Specimens", WO EP US CN JP CA US20190064037A1; Inventos: Edward Stuart Boyden, Andrew Hanno Beck, Yongxin Zhao, Octavian Bucur; Current Assignees: Beth Israel Deaconess Medical Center Inc Massachusetts Institute of Technology,; Priority 2016-02-25 • Filed 2017-02-24 • Published 2019-02-28".
    14. ^"Patent "Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy", WO US US11802872B2; Inventos: Edward Stuart Boyden, Andrew Hanno Beck, Yongxin Zhao, Octavian Bucur; Current Assignees: Beth Israel Deaconess Medical Center Inc Massachusetts Institute of Technology; Priority 2017-02-24 • Filed 2019-08-15 • Granted 2023-10-31 • Published 2023-10-31".
    15. ^Bucur, O.; Zhao, Y. (2018)."Bucur O, Zhao Y. Nanoscale Imaging of Kidney Glomeruli Using Expansion Pathology. Front Med (Lausanne). 2018 Nov 21;5:322. doi: 10.3389/fmed.2018.00322. PMID: 30519560; PMCID: PMC6259469".Frontiers in Medicine.5: 322.doi:10.3389/fmed.2018.00322.PMC 6259469.PMID 30519560.
    16. ^Fortner, A.; Bucur, O. (2024)."Fortner A, Bucur O. Multiplexed spatial transcriptomics methods and the application of expansion microscopy. Front Cell Dev Biol. 2024 Jul 22;12:1378875. doi: 10.3389/fcell.2024.1378875. PMID: 39105173; PMCID: PMC11298486".Frontiers in Cell and Developmental Biology.12.doi:10.3389/fcell.2024.1378875.PMC 11298486.PMID 39105173.
    17. ^"ROGEN Project".
    18. ^"ICDG proiecte".
    19. ^"Gala Cercetarii Românești - Dr. Octavian Bucur a primit premiul la secțiunea tineri cercetători".
    20. ^"Gala Premiilor Marii Loji Nationale si Academiei Romane - Dr. Octavian Bucur a primit premiul Carol Davila pentru Medicina".

    Category:Romanian physiciansCategory:Romanian scientistsCategory:Genomics

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