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Domoprednate

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Domoprednate
Clinical data
Trade namesStermonid
Other namesRo 12-7024; 11β-Hydroxy-D-homopregna-1,4-diene-3,20-dione 17α-butyrate
Routes of
administration		Topical
Drug classCorticosteroid;Glucocorticoid
Identifiers
  • [(1R,4aS,4bS,10aR,10bS,11S,12aS)-1-Acetyl-11-hydroxy-10a,12a-dimethyl-8-oxo-2,3,4,4a,4b,5,6,10b,11,12-decahydrochrysen-1-yl] butanoate
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.060.441Edit this at Wikidata
Chemical and physical data
FormulaC26H36O5
Molar mass428.569 g·mol−1
3D model (JSmol)
  • CCCC(=O)O[C@@]1(CCC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C(=O)C
  • InChI=1S/C26H36O5/c1-5-7-22(30)31-26(16(2)27)12-6-8-20-19-10-9-17-14-18(28)11-13-24(17,3)23(19)21(29)15-25(20,26)4/h11,13-14,19-21,23,29H,5-10,12,15H2,1-4H3/t19-,20-,21-,23+,24-,25-,26-/m0/s1
  • Key:IYBYNRHXGXDDDS-VRRJBYJJSA-N

Domoprednate (brand nameStermonid; developmental code nameRo 12-7024) is asyntheticglucocorticoidcorticosteroid which was developed in the late 1970s and 1980s.[1][2][3][4][5]

References

[edit]
  1. ^J. Elks (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 465–.ISBN 978-1-4757-2085-3.
  2. ^Schmidt H, Hjorth N, Holm P (1984). "A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses".Dermatologica.168 (3):127–30.doi:10.1159/000249683.PMID 6370748.
  3. ^Serup J, Holm P (1985). "Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo".Dermatologica.170 (4):189–94.doi:10.1159/000249529.PMID 3888708.
  4. ^Christiansen JV, Foged E, Holm P, Jørgensen AS, Reymann F (1985). "The treatment of psoriasis with 0.1% domoprednate (a D-homocorticosteroid) and 0.1% betamethasone valerate ointment. A double-blind, randomized trial".Dermatologica.170 (4):195–8.doi:10.1159/000249530.PMID 3888709.
  5. ^Schmidt H, Hjorth N, Holm P (1987). "Domoprednate, a new nonhalogenated topical steroid: comparison to hydrocortisone butyrate".Dermatologica.175 (3):145–7.doi:10.1159/000248813.PMID 3653463.


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