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| Clinical data | |
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| Trade names | Slentrol |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Protein binding | High[1] |
| Metabolism | Liver |
| Eliminationhalf-life | 5–18 hours (increased with repeated dosing) |
| Excretion | Feces, urine |
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| UNII | |
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| ChEMBL | |
| CompTox Dashboard(EPA) | |
| Chemical and physical data | |
| Formula | C40H33F3N4O3 |
| Molar mass | 674.724 g·mol−1 |
| 3D model (JSmol) | |
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Dirlotapide is a drug used to treat obesity in dogs.[1] It is manufactured byPfizer andZoetis and marketed under the brand nameSlentrol.[citation needed]
It works as a gut-selectivemicrosomal triglyceride transfer protein (MTTP or MTP) inhibitor.[2] This blocks the assembly and release oflipoproteins into the bloodstream, thereby reducing fat absorption.[medical citation needed] It also elicits asatiety signal from lipid-filled cells lining the intestine.[medical citation needed]
It is supplied as an oral solution. It is not intended for use in humans, cats, birds, rodents, or other animals.
Dirlotapide is used to manage obesity in dogs and helps by reducing appetite. It is used as part of an overall weight control program that also includes proper diet and exercise, under the supervision of a veterinarian. Side effects may include vomiting, diarrhea, lethargy, drooling, or uncoordination. Allergic reaction to the medication may include, facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma.
On January 5, 2007, theU.S. Food and Drug Administration (FDA) approved Slentrol, the first time the FDA has approved a drug for obese dogs.[3][4]
However, concerns have since been raised, since 2010, about adverse effects[5] that might more strongly affect particularbreeds.[6]
Dirlotapide (under the brand name Slentrol) was authorized for use in the EU by theEuropean Medicines Agency for helping weight loss in dogs, but has since been withdrawn from the market in the EU.[7]
