DiPT was first described in thescientific literature by 1959.[16] The basic properties of DiPT in humans were described byAlexander Shulgin in 1976[17] and its effects were described in detail by Shulgin in subsequent publications in the 1980s[18][2][19][3] and in his 1997 bookTiHKAL (Tryptamines I Have Known and Loved).[1] DiPT was encountered as a noveldesigner drug in 2005.[20] However, it appears to be little-usedrecreationally compared to other psychedelic drugs, perhaps due to its unusual effects.[18][7]
In his bookTiHKAL (Tryptamines I Have Known and Loved) and other publications,Alexander Shulgin lists DiPT's dose range as 25 to 100mgorally and itsduration as 6 to 8hours.[1] In other publications however, he variably gives an effective dose range of 20 to 50mg orally, a dose range of 40 to 100mg orally, and a listed dose of 80mg orally, as well as a shorter duration of 4hours at lower doses and 5hours at a higher dose.[2][3][4][5] Per Shulgin, the full spectrum of effects of DiPT occur at a dose of 50mg, while a dose of 80mg has the same activity as a 50mg dose and only results in an intensification of these effects.[2][3] A widerrecreational dose range for DiPT of 15 to 150mg or more orally has also been reported, with a typical dose estimate of about 50mg.[21] According to Shulgin, testing of DiPT started at a dose of 0.5mg and gradually titrated up in 9human volunteers, with threshold effects occurring at a dose of 16mg orally.[2] There was also a report of 250mg orally inTiHKAL, with apparently very strong effects.[1] Theonset of DiPT is 20 to 30minutes or up to 1hour, peak effects occur after 1.5 to 2hours, and full effects last for 1 to 2hours.[1][2][3] In addition to oral administration,TiHKAL included a report of 8mg DiPTsmoked, with an onset of 4 to 8minutes and a plus-two rating on theShulgin Rating Scale.[1]
In major contrast to most other knownserotonergic psychedelics, which are primarilyvisual in their effects, the effects of DiPT are unusual in that they are primarily or exclusivelyauditory.[6][1][2][19][3][22] It is said to produce remarkable and extraordinary changes tosound perception, for instance ofvoices andmusic.[6][1][2][3] DiPT reduces the perceivedpitch (frequency) of sounds, causing an unusualtonal shift of all frequencies to a lower pitch.[6][7][1][2][3] It also causes distortion of pitch as well as of thetimbre (tone quality) of sounds.[1][2][19][3] As an example of its effects on pitch, DiPT makes peoples' voices sound much lower or deeper, like womens' voices being heard in bass tones or peoples' voices sound as if they have a bad cold.[6][1][2][3] Voices are said to sound very similar to a single side-band radio signal being mistuned to the low side of the center frequency.[1] Despite these changes however, there were no effects on clarity of speech, and speech comprehension and interpretation were described as normal.[1]
DiPT makes music sound out of key and completelydisharmonious, for instance piano playing sounding like a "bar-room disaster".[1][3] However, single tones were said to sound normal aside from pitch changes.[1] DiPT does not cause a simple, linear, or proportional decrease in pitch, but decreases pitch by a fixed value.[1][3] As a result, proportionality is lost, in turn resulting in complete harmonic distortion, jarring distortions of harmonic intervals, and music feeling qualitatively "wrong".[6][1][2][3] An analogy given for this was someone having their thumb on anLP record and making everything come out at a 50 to 75% speed.[1] In terms of other sounds, telephone ringing sounds "partly underwater" with DiPT.[1] The drug causes abrupt sounds to have "golden spikes" attached to them as "after-sounds".[1] DiPT was reported to cause all familiar sounds to become foreign, even the mere chewing of food.[1] Sounds are said to be perceived as amplified or more intense and there is said to be a decrease in high-frequency acuity.[1][19] The auditory and harmonic distortion with DiPT is described as intense or extreme, even at relatively low doses like 40mg orally.[1][5] There is said to be variability between individuals in terms of the auditory effects of DiPT.[2][3]
Shulgin felt that DiPT could potentially be a useful tool inscientific research on theauditory system.[6][7][1][19] He speculated that it might be able to help locate the pitch center of the brain, for instance if used inpositron emission tomography (PET)imaging.[1] A small study involving DiPT administered to two people withperfect pitch was conducted and findings shared with Shulgin.[6][1] It assessed whether there was some relationship between a note's pitch and the perceived pitch of the note.[1] No meaningful relationship was found, except reinforcement of the notion that the pitch decrease with DiPT is not linear and that there is true distortion instead of a simple pitch drop.[1] Interestingly, the plot of the error for each note against elapsed time provided an almost-quantitative measurement of DiPT's intensity and time-course of effects.[1] In the same study, pre-treatment with low doses ofMDMA resulted in exaggeration of auditory distortion with DiPT, including an enhanced sound intensity that verged on being painful.[1] Aside from research on the auditory system, there has also been interest in DiPT in the study of music andlanguage processing.[6]
In terms of its psychedelic-type effects, DiPT is said to produce only auditory changes.[6][7][3] One report observed auditory changes but no effects whatsoever in a quiet environment.[1] The subject remarked that if they were deaf, they would have assumed that DiPT was an inactive compound.[1] The drug is specifically said to produce no visual changes at all[5] or that visual effects with it are non-existent.[3] Relatedly, there was novisual distortion with DiPT at any time and there was noclosed-eyeimagery.[2] The drug is said to lack the intensesensory disturbances orhallucinogenic effects characteristic of other psychedelics likedimethyltryptamine (DMT) andpsilocybin.[6][2] Relatedly, DiPT produces no changes invision,taste, orsmell.[6][1] Additionally, it is said to produce little to noeuphoria.[2][3] Moreover, its experience was described as passive and neutral rather than as pleasant or unpleasant, or that it had a somewhat neutral–negative response.[2][3] Because of its lack of classical psychedelic-like effects, some authors have gone so far as to conclude that DiPT "distorts auditory perception and does not produce psychedelic effects".[8] Aside from hallucinogenic-related effects, DiPT is said to producelethargy and a desire to lie down and remain that way, which are particularly prominent during the peak.[2] It is also reported to cause distance between oneself and one's surroundings and/or feelings, with these effects neither being disturbing nor stimulating.[2] Owing to its selective auditory effects, the outcomes of DiPT experiences may be less dependent onset and setting than those of other psychedelics.[6]
Although DiPT produces selective auditory effects at typical doses, it appears to produce effects more similar to those of classical serotonergic psychedelics likeLSD at higher doses.[1][8] For example, in one report inTiHKAL that employed DiPT at a very high dose of 250mg orally, the person described being spoken to and reassured by a "spirit", a feeling of foreboding, that "the light was there" but that DiPT was the "body of Satan", that they felt like they had been sent to an "anti-universe" where everything looked the same as normal but was a cold and empty imitation, and that they felt like a "fallen angel".[1] In addition to these effects, the person reported very strong auditory effects, such as mens' voices sounding like frogs and children sounding like they were speaking through synthesizers to imitate outer-space people in science-fiction movies.[1] While DiPT may be able to produce more classically psychedelic effects at high doses, the precise effective dose range for these effects is not well-defined.[8]
Other tryptamines reported to cause DiPT-esque sound distortion have included2-methyl-DMT,2-methyl-DET, and5-MeO-DiPT.[1] Conversely, auditory changes or distortions with other psychedelics, including DMT,diethyltryptamine (DET), andethylisopropyltryptamine (EiPT) among many others, are described as mild, rare, or absent.[1][2] Similarly, auditory changes were not mentioned withmethylisopropyltryptamine (MiPT) or5-MeO-MiPT, except that these drugs produced enhanced auditory acuity and sound discrimination.[1] Although both DiPT and 5-MeO-DiPT can produce notable changes in auditory perception, DiPT's effects in general are said to differ from those of 5-MeO-DiPT's in most respects.[2] Moreover, 5-MeO-DiPT was reported to cause "some" musical sound distortion, specifically in terms of musical character and interpretation, but there were no apparent changes to harmonic structure in contrast to DiPT.[1] Shulgin speculated that2-methyl-DiPT could be an interesting compound in terms of attempting to develop another psychedelic specifically affecting the auditory system, but he did notsynthesize or test it.[1]
Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified.Refs:[24][13][9][10][11][12][25]
DiPT fully substitutes fordimethyltryptamine (DMT) andDOM and partially substitutes forLSD in rodentdrug discrimination tests.[9][8] Conversely, it does not substitute forcocaine,methamphetamine, orMDMA.[9] When DiPT is used as the training drug, LSD, DOM, andMDMA fully substitute for DiPT while DMT only partially substitutes for DiPT and methamphetamine fails to substitute.[26] Its stimulus properties in drug discrimination tests are partially blocked by the serotonin 5-HT2A receptorantagonistvolinanserin and by the serotonin 5-HT2C receptor antagonistSB-242084.[14][12] This is in contrast to the case of the related psychedelic DMT, wherein volinanserin fully blocks its stimulus properties and SB-242084 has minimal influence.[14][12] Nonetheless, it was concluded that the serotonin 5-HT2A receptor primarily mediates theinteroceptive effects of DiPT in rodents.[14][12] Besides serotonin receptors, themetabotropic glutamatemGlu2 andmGlu3 receptoragonistLY-379268 had minimal effects on the stimulus properties of DiPT, whereas the mGlu2 and mGlu3 receptorantagonistLY-341495 potentiated DiPT discrimination.[14][12]
Similarly to DMT and other psychedelics, DiPT produces thehead-twitch response, a behavioral proxy ofpsychedelic-like effects, in rodents, and this effect is blocked by volinanserin.[12][8] In addition, DiPT produceshypolocomotion.[9] The drug also producesconvulsions at high doses in rodents.[9]
The uniqueauditory effects of DiPT in humans have not yet been properly evaluated or demonstrated in animals.[7]
2-Methyl-DiPT, the 2-methylderivative of DiPT, was mentioned byAlexander Shulgin in his bookTiHKAL (Tryptamines I Have Known and Loved) as a potentially interestinganalogue of DiPT that might likewise produce selective auditory effects.[1] This was based on findings that other 2-methylated tryptamines like2-methyl-DMT and2-methyl-DET have also uniquely been found to produce DiPT-like auditory effects.[1] However, 2-methyl-DiPT is not known to have beensynthesized or tested.[1] A notable analogue of 2-methyl-DiPT is2-methyl-iPALT.[27]
DiPT was first described in thescientific literature by R. B. Barlow and colleagues by 1959.[16]Alexander Shulgin disclosed the basic properties of DiPT in humans in 1976 based on unpublished findings of his cited to 1974.[17][28] Subsequently, Shulgin described DiPT, along with5-MeO-DiPT, in much greater detail in a 1980journal article.[2] He also described it in further detail in other articles published in the 1980s,[18][19][3] as well as in his 1997 bookTiHKAL (Tryptamines I Have Known and Loved).[1] DiPT was encountered as a noveldesigner drug inEurope in 2005.[20] However, DiPT appears to be relatively little usedrecreationally compared to other psychedelic drugs.[18] This may be related to its unusual effects, including lacking the typical recreational effects associated with psychedelic drugs.[7]
DiPT is notscheduled at the federal level in theUnited States,[29] but it could be considered an analog of5-MeO-DiPT, in which case purchase, sale, or possession for human consumption or illicit use that is not for scientific or industrial purposes could be prosecuted under theFederal Analog Act. Some of the people arrested inOperation Web Tryp were selling DiPT, however the drug is not explicitly forbidden or outlawed.
However the US Drug Enforcement Agency (DEA) withdrew a proposal to ban five psychedelic substances including 4-Hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT), N-Isopropyl-5-Methoxy-N-Methyltryptamine (5-MeO-MiPT) and N,N-Diisopropyltryptamine (DiPT). DEA withdrew the proposed listing as schedule 1 banned substance after a public hearing in 2022.[30]
"DiPT (N,N-Diisopropyltryptamine)" is a Schedule Icontrolled substance in the state ofFlorida making it illegal to buy, sell, or possess in Florida.[31]
^abcdefghijklmnCorey V, Halpern JH, Passie T (2012). "Psychoactive Substances".Hallucinations. New York, NY: Springer New York. pp. 297–316.doi:10.1007/978-1-4614-0959-5_22.ISBN978-1-4614-0958-8. Retrieved9 November 2025.22.2.3.2 DiPT A member of the tryptamine chemical family, diisopropyltryptamine (DiPT) is a fascinating substance because, unlike most hallucinogens, its effects are predominantly auditory. It is also possibly less sensitive than other hallucinogens to the mindset of the user, the setting in which it is ingested, and other psychological considerations, perhaps because the auditory system has become less salient to the human organism as we have evolved into a vision-based species. In general, auditory pitch is perceived as lower than normal, and harmonious sounds lose their resonance with one another. This dissonance is even perceived by people with perfect pitch, which has some implications about where in the processing stream DiPT's effects occur. Voices are also altered and disharmonious with one another (Shulgin and Shulgin 1997 ) . DiPT has few other known effects; it would seem to call for further investigation from those interested in the neurology of sound, music, and verbal language processing. For example, it would be fascinating to know the effects of this substance on perceptions of tonal languages such as Chinese, Huichol, or Dogon; would it alter the words perceived as being spoken?
^abShulgin AT (1976). "Psychotomimetic Agents".Psychopharmacological Agents. Elsevier. pp. 59–146.doi:10.1016/b978-0-12-290559-9.50011-9.ISBN978-0-12-290559-9. Retrieved9 November 2025.[5-MeO-DMT] has been shown to be a centrally active drug in animal studies (Gessner and Page, 1962; Gallagher et al., 1964) and to be active parenterally in man. Like [DMT], it is not active orally, although the N,N-diisopropyl homolog [(DiPT)], as with the hindered dialkyl tryptamines mentioned earlier, is effective by the oral route (A. T. Shulgin, unpublished data, 1974). [...] With this in mind, three comments should be made. It is "knowledge" within the anonymous underground drug publications that not only is the [DPT] homolog mentioned above active orally but also that the diisopropyl counterpart [(DiPT)] is especially so.
^abcdZamberlan F, Sanz C, Martínez Vivot R, Pallavicini C, Erowid F, Erowid E, et al. (8 November 2018)."The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines".Frontiers in Integrative Neuroscience.12 54.doi:10.3389/fnint.2018.00054.PMID30467466.A large body of anecdotal experiences supports the existence of differences in the subjective effects of serotonergic psychedelics, in particular concerning those elicited by relatively novel synthetic derivatives of phenethylamines (i.e., mescaline analogs) and tryptamines (i.e., DMT analogs). A frequently cited example is that of N,N-Diisopropyltryptamine (DiPT), a substituted tryptamine and 5-HT1A/2A agonist remarkable for producing auditory distortions, in contrast to the predominantly visual effects of classic psychedelics (Shulgin and Carter, 1979; Shulgin and Shulgin, 1997; Kometer and Vollenweider, 2016). [...] • DiPT (N,N-Diisopropyltryptamine): substituted tryptamine, first synthesized and tested by Shulgin and Carter (1979). [...] A total of 16 reports were obtained for mescaline, 143 for 2C-B, 206 for 2C-E, 101 for 2C-T-2, 36 for DOB, 32 for DOI, 23 for DOM, 19 for TMA-2, 63 for MDA, 770 for MDMA, 236 for DMT, 247 for 5-MeO-DMT, 69 for 5-MeO-MiPT, 45 for DiPT, 182 for 5-MeO-DiPT, 137 for DPT, 718 for LSD, 32 for ibogaine, 64 for 2C-C, 383 for 2C-I, 57 for 2C-P, 16 for 2C-T-4, 171 for 2C-T-7, 48 for 2C-D, 144 for 25I-NBOMe, 51 for 4-OH-MET, 109 for 5-MeO-AMT, 208 for 4-OH-DiPT and 8 for psilocin/psilocybin.
^abcdefShulgin AT, Shulgin LA, Jacob P (May 1986)."A protocol for the evaluation of new psychoactive drugs in man".Methods and Findings in Experimental and Clinical Pharmacology.8 (5):313–320.PMID3724306. Archived fromthe original on 2025-07-12.Sensory amplification: A deceptively simple tryptamine DIPT (N,N-diisopr()pyltryptamine) has been reported to amplify and distort the auditory sensory input signals (2) in preference to the more frequently seen visual distortions. This modality is closer to the usual symptomology of endogenous schizophrenia, and may well serve as a discriminating tool for differential research.
^Larøi F, Sommer IE, Blom JD, Fernyhough C, Ffytche DH, Hugdahl K, et al. (June 2012)."The characteristic features of auditory verbal hallucinations in clinical and nonclinical groups: state-of-the-art overview and future directions".Schizophrenia Bulletin.38 (4):724–733.doi:10.1093/schbul/sbs061.PMC3406519.PMID22499783.Auditory hallucinations can sometimes be triggered by the use of—or withdrawal from—illicit substances such as alcohol, cannabis, amphetamines, cocaine, [LSD], and [DMT]. Generally speaking, hallucinogens are more likely to induce visual than auditory misperceptions. If auditory misperceptions occur at all, they tend to do so in the context of compound hallucinations. A notable exception is diisopropyltryptamine (DiPT), a hallucinogenic of the tryptamine family, which primarily affects auditory pitch.
^Hill SL, Thomas SH (October 2011). "Clinical toxicology of newer recreational drugs".Clinical Toxicology.49 (8):705–719.doi:10.3109/15563650.2011.615318.PMID21970769.Other unsubstituted simple synthetic tryptamines are N,N-diallyltryptamine (DALT), diethyltryptamine (DET), di-isopropyltryptamine (DiPT) and dipropyltryptamine (DPT) (see Fig. 5). Each is active after ingestion, with serotonin-mediated visual hallucinations the main clinical effect. DiPT is unusual in that it produces primarily auditory hallucinations, with tinnitus as a side effect. 154
^"Kᵢ Database".PDSP. 25 March 2025. Retrieved25 March 2025.
^US 20240277665A1, Daley PF, Cozzi NV, Callaway WB, "Asymmetric allyl tryptamines", issued 4 March 2024, assigned to Alexander Shulgin Research Institute Inc.
