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Dihydrokainic acid

From Wikipedia, the free encyclopedia
Dihydrokainic acid
Names
IUPAC name
(3S,4R)-3-(Carboxymethyl)-4-isopropyl-L-proline
Systematic IUPAC name
(2S,3S,4R)-3-(2-Hydroxy-2-oxoethyl)-4-(propan-2-yl)pyrrolidine-2-carboxylic acid
Other names
Dihydrokainate; DHK
Identifiers
3D model (JSmol)
84942
ChEBI
ChEMBL
ChemSpider
UNII
  • InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
    Key: JQPDCKOQOOQUSC-OOZYFLPDSA-N
  • CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
Properties
C10H17NO4
Molar mass215.249 g·mol−1
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302,H312,H332
P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P312,P304+P340,P312,P322,P330,P363,P501
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Dihydrokainic acid is anorganic compound that contains twocarboxylic acid functional groups, making it adicarboxylic acid. It is an inhibitor of theGLT-1 glutamate transporter.[1]

See also

[edit]

References

[edit]
  1. ^Kawahara, K; Hosoya, R; Sato, H; Tanaka, M; Nakajima, T; Iwabuchi, S (2002). "Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures".Glia.40 (3):337–49.doi:10.1002/glia.10133.hdl:2115/5937.PMID 12420313.S2CID 14246291.


Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
ASTTooltip Aspartate aminotransferase
ALTTooltip Alanine aminotransferase
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase
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