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Dienedione

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Dienedione
Clinical data
Other names19-Nor-4,9(10)-androstadienedione; Estradienedione, 19-Norandrosta-4,9(10)-diene-3,17-dione; Estra-4,9(10)-diene-3,17-dione
Routes of
administration
Oral
Legal status
Legal status
Identifiers
  • 13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,17-dione
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
CompTox Dashboard(EPA)
ECHA InfoCard100.112.341Edit this at Wikidata
Chemical and physical data
FormulaC18H22O2
Molar mass270.372 g·mol−1
3D model (JSmol)
  • C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CCC2=O
  • InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,15-16H,2-9H2,1H3/t15-,16+,18+/m1/s1
  • Key:BHTWZQKERRCPRZ-RYRKJORJSA-N
  (verify)

Dienedione, also known asestra-4,9-diene-3,17-dione, is asynthetic,orally activeanabolic-androgenic steroid (AAS) of the19-nortestosterone group that was never introduced for medical use. It is thought to be aprohormone ofdienolone.[1] The drug became a controlled substance in the US on January 4, 2010,[2] and is classified as a Schedule III anabolic steroid under the United StatesControlled Substances Act. Previous to this, it was sold as abodybuilding supplement within the United States, and often mistakenly marketed as aprohormone fortrenbolone, a veterinary steroid. Prior to its scheduling, it was part of a number of supplements that were seized during FDA enforcement ofBodybuilding.com for selling unapproved new drugs.[3] The actual active metabolite, dienolone, is almost identical to trenbolone structurally, but lacks the C11double bond.

Dienedione use is also prohibited in horses. In addition, small amounts are endogenously produced in horses.[4]

See also

[edit]

References

[edit]
  1. ^"Rules - 2009 - Final Rule: Classification of Three Steroids as Schedule III Anabolic Steroids Under the Controlled Substances Act".www.deadiversion.usdoj.gov. Retrieved1 June 2017.
  2. ^"Rules - 2009 - Final Rule: Classification of Three Steroids as Schedule III Anabolic Steroids Under the Controlled Substances Act".www.deadiversion.usdoj.gov. Retrieved1 June 2017.
  3. ^Office of Regulatory Affairs."Enforcement Reports - Enforcement Report for July 7, 2010".www.fda.gov. Archived fromthe original on July 10, 2010. Retrieved1 June 2017.
  4. ^Ho HS, Ho EN, Wong WT (January 2025). "Endogenous nature of estra-4,9-diene-3,17-dione in entire male horses".Drug Testing and Analysis.17 (1):75–87.doi:10.1002/dta.3685.PMID 38532598.
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists


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