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Dianethole

From Wikipedia, the free encyclopedia
Dianethole
Names
IUPAC name
1-Methoxy-4-[(4E)-5-(4-methoxyphenyl)-4-methylpent-4-en-2-yl]benzene[1]
Identifiers
3D model (JSmol)
  • InChI=1S/C19H22O2/c1-15(17-9-13-19(21-3)14-10-17)5-4-6-16-7-11-18(20-2)12-8-16/h4,6-15H,5H2,1-3H3
    Key: NWLMIETUAKULHS-UHFFFAOYSA-N
  • C1=CC(=CC=C1C(C)CC=CC2=CC=C(C=C2)OC)OC
Properties
C19H22O2[1]
Molar mass282.3768 g/mol[1]
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Dianethole is anaturally occurringorganic compound that is found inanise andfennel.[1][2] It is adimericpolymer ofanethole.[1][3][4] It hasestrogenic activity, and along with anethole andphotoanethole, may be responsible for the estrogenic effects of anise and fennel.[1][5][6][7][8] These compounds bear resemblance to the estrogensstilbene anddiethylstilbestrol, which may explain their estrogenic activity.[1][9] In fact, it is said that diethylstilbestrol and related drugs were originally modeled after dianethole and photoanethole.[1][10]

See also

[edit]

References

[edit]
  1. ^abcdefghAlbert-Puleo, Michael (1980). "Fennel and anise as estrogenic agents".Journal of Ethnopharmacology.2 (4):337–344.doi:10.1016/S0378-8741(80)81015-4.ISSN 0378-8741.PMID 6999244.
  2. ^James A. Duke (10 November 2000).Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants: Herbal Reference Library. CRC Press. pp. 257, 458.ISBN 978-0-8493-3865-6.
  3. ^K. V. Peter (21 September 2012).Handbook of Herbs and Spices. Elsevier Science. pp. 142–.ISBN 978-0-85709-568-8.
  4. ^Finn Sandberg; Desmond Corrigan (4 October 2001).Natural Remedies: Their Origins and Uses. CRC Press. pp. 124–.ISBN 978-0-415-27202-5.
  5. ^Steven Foster (12 November 2012).Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. Routledge. pp. 157–.ISBN 978-1-136-74501-0.
  6. ^Thomas DeBaggio; Arthur O. Tucker (1 September 2009).The Encyclopedia of Herbs: A Comprehensive Reference to Herbs of Flavor and Fragrance. Timber Press. pp. 240–.ISBN 978-1-60469-134-4.
  7. ^Ikhlas A. Khan; Ehab A. Abourashed (21 September 2011).Leung's Encyclopedia of Common Natural Ingredients: Used in Food, Drugs and Cosmetics. John Wiley & Sons. pp. 3–.ISBN 978-1-118-21306-3.
  8. ^T. K. Lim (2 February 2013).Edible Medicinal And Non-Medicinal Plants: Volume 5, Fruits. Springer Science & Business Media. pp. 50–.ISBN 978-94-007-5653-3.
  9. ^Kerry Bone; Simon Y. Mills (2013).Principles and Practice of Phytotherapy,Modern Herbal Medicine,2: Principles and Practice of Phytotherapy. Elsevier Health Sciences. pp. 559–.ISBN 978-0-443-06992-5.
  10. ^Jordan, V. C. (2009). "A Century of Deciphering the Control Mechanisms of Sex Steroid Action in Breast and Prostate Cancer: The Origins of Targeted Therapy and Chemoprevention".Cancer Research.69 (4):1243–1254.doi:10.1158/0008-5472.CAN-09-0029.ISSN 0008-5472.PMID 19208829.
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown


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