Movatterモバイル変換

Dexetimide

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Dexetimide
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	N04AA08 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances)^[1]
Identifiers
IUPAC name 3-(1-benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione
CAS Number	21888-98-2^N
PubChemCID	30843
IUPHAR/BPS	354
DrugBank	DB08997^N
ChemSpider	28615^Y
UNII	43477QYX3D
KEGG	D03711^Y
ChEMBL	ChEMBL1908364^N
CompTox Dashboard(EPA)	DTXSID701043218
Chemical and physical data
Formula	C₂₃H₂₆N₂O₂
Molar mass	362.473 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C2NC(=O)CCC2(c1ccccc1)C4CCN(Cc3ccccc3)CC4
InChI InChI=1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1^Y Key:LQQIVYSCPWCSSD-HSZRJFAPSA-N^Y
^NY (what is this?) (verify)

Dexetimide (brand nameTremblex) is apiperidine anticholinergic. It is amuscarinic antagonist that is used to treatdrug induced parkinsonism. Dexetimide was discovered atJanssen Pharmaceutica in 1968.^[2]^[3]

^Anvisa (2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-04-04).Archived from the original on 2023-08-03. Retrieved2023-08-16.
^Dom R, Van Lommel R, Baro F (1971). "A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent".Acta Psychiatrica Scandinavica.47 (4):399–410.doi:10.1111/j.1600-0447.1971.tb03697.x.PMID 4947805.S2CID 10591790.
^Huygens H, Vereecken JL, Tanghe A (1973). "Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action".Psychiatria, Neurologia, Neurochirurgia.76 (4):251–9.PMID 4581374.

DA precursors	Levodopa^# (+benserazide,+carbidopa,+carbidopa/entacapone) Foslevodopa (+foscarbodipa) Melevodopa (+carbidopa)
DA receptor agonists	Ergoline:Bromocriptine Cabergoline Dihydroergocryptine Lisuride Pergolide Non-ergoline:Apomorphine Piribedil Pramipexole Ropinirole Rotigotine Talipexole
MAO-B inhibitors	Rasagiline Safinamide Selegiline
COMT inhibitors	Entacapone Opicapone Tolcapone
AAAD inhibitors	Benserazide (+levodopa) Carbidopa^# (+carbidopa,+melevodopa,+carbidopa/entacapone) Foscarbidopa (+foslevodopa)