| Destrin (actin binding protein) | |||||||
|---|---|---|---|---|---|---|---|
 Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.[1] | |||||||
| Identifiers | |||||||
| Symbol | DSTN | ||||||
| Alt. symbols | ADF | ||||||
| NCBI gene | 11034 | ||||||
| HGNC | 15750 | ||||||
| OMIM | 609114 | ||||||
| RefSeq | NM_006870 | ||||||
| UniProt | P60981 | ||||||
| Other data | |||||||
| Locus | Chr. 20p12.1 | ||||||
| |||||||
Destrin orDSTN (also known asactin depolymerizing factor orADF) is aprotein which in humans is encoded by theDSTNgene.[2][3][4] Destrin is a component protein inmicrofilaments.
The product of this gene belongs to theactin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.[2]
The tertiary structure of destrin was determined by the use of triple-resonance multidimensional nuclear magnetic resonance, orNMR for short.[1] The secondary and tertiary structures of destrin are similar to thegelsolin family which is another actin-regulating protein family.
There are three ordered layers to destrin which is a globular protein. There is a centralβ sheet that is composed of one parallel strand and three antiparallel strands. This β sheet is between a longα helix along with a shorter one and two shorter helices on the opposite side. The four helices are parallel to the β strands.[1]
In a variety ofeukaryotes, destrin regulates actin in the cytoskeleton. Destrin binds actin and is thought to connect it as gelsolin segment-1 does. Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever actin filaments.[1]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.