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| Other names | DMT; Madol; Pheraplex; 3-Desoxy-17α-methyl-δ2-5α-dihydrotestosterone; 3-Desoxy-17α-methyl-δ2-DHT; 17α-Methyl-5α-androst-2-en-17β-ol; NSC-63329; SC-11977 |
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| Routes of administration | By mouth |
| Drug class | Androgen;Anabolic steroid |
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| Formula | C20H32O |
| Molar mass | 288.475 g·mol−1 |
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Desoxymethyltestosterone (DMT), known by the nicknamesMadol andPheraplex, is asynthetic andorally activeanabolic–androgenic steroid (AAS) and a17α-methylatedderivative ofdihydrotestosterone (DHT) which was never marketed for medical use. It was one of the firstdesigner steroids to be marketed as aperformance-enhancing drug toathletes andbodybuilders.
Desoxymethyltestosterone is sometimes abbreviated as DMT, though it should not be confused with thehallucinogendimethyltryptamine, which is also known by the same acronym.
In animal studies, desoxymethyltestosterone has been found to bind to theandrogen receptor (AR) about half as strongly as DHT, and to causeside effects that are typical of 17α-alkylated AAS, such asliver damage andleft ventricular hypertrophy when taken in higher doses.[2]
Desoxymethyltestosterone is unusual in that it is structurally a 2-ene compound, lacking the 3-keto group present in almost all commercial AAS (withethylestrenol being a rare and notable exception). This does not mean it is a weak compound, and clinical research has determined that it is a fairly potent oral agent.[2] Rat studies indicate that desoxymethyltestosterone has an anabolic effect 160% that of testosterone while being only 60% as androgenic, giving it a Q ratio of 6.5:1.[3] Because of this favorable ratio, experiments inorchiectomized rats have demonstrated that treatment with desoxymethyltestosterone resulted only in a stimulation of the weight of the levator ani muscle; theprostate andseminal vesicle weights remained unaffected leading the authors of one study to characterize desoxymethyltestosterone as a powerful AAS with attributes of aselective androgen receptor modulator (SARM) and some indication oftoxicity.[2]
Desoxymethyltestosterone, also known as 3-desoxy-17α-methyl-δ2-5α-dihydrotestosterone (3-desoxy-17α-methyl-δ2-DHT) or as 17α-methyl-5α-androst-2-en-17β-ol, is asyntheticandrostanesteroid and a17α-alkylatedderivative ofdihydrotestosterone (DHT).
Desoxymethyltestosterone was invented in 1961 by Max Huffman who obtained a patent on the compound the same year.[2] It was described in the scientific literature in 1963.[2] However, it was never brought to market as a commercial drug.[4][2] Desoxymethyltestosterone was rediscovered by chemist, AAS enthusiast, and amateur bodybuilderPatrick Arnold in 2005. Arnold produced desoxymethyltestosterone and supplied it to Victor Conte ofBay Area Laboratory Co-operative (BALCO), an American nutritional supplement company and steroid supplier.[5]
DMT became a controlled substance in the US on January 4, 2010, and is classified as aSchedule IIIanabolic steroid under the United StatesControlled Substances Act along withboldione anddienedione.[6][7][8][9] The substance had come under scrutiny after it was found to be present in several over-the-counterbodybuilding supplements.[10]
