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| ECHA InfoCard | 100.042.305 |
| Chemical and physical data | |
| Formula | C14H21NO15S |
| Molar mass | 475.37 g·mol−1 |
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Dermatan sulfate is aglycosaminoglycan (formerly called a mucopolysaccharide) found mostly inskin, but also inblood vessels,heart valves,tendons, andlungs.
It is also referred to aschondroitin sulfate B,[1] although it is no longer classified as a form of chondroitin sulfate by most sources. The formula is C14H21NO15S. This carbohydrate is composed of linear polymers of disaccharide units that contain,iduronic acid (IdoA) andN-acetyl galactosamine (GalNAc). These repeating units are sulfated at a variety of positions.[2] Dermatan sulfate is a component of the compoundsulodexide.[3]
Dermatan sulfate may have roles incoagulation,cardiovascular disease,carcinogenesis,infection,wound repair, maintaining the shape of galactosamine 4-sulfate, skin, andfibrosis.[1]
Dermatan sulfate accumulates abnormally in several of themucopolysaccharidosis disorders.
An excess of dermatan sulfate in themitral valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valvetissue and ultimately,mitral valve prolapse (into theleft atrium) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose thepatient tomitral annular calcification.Mitral valve insufficiency can lead to eccentric (volume dependent or dilated)hypertrophy and eventuallyleft heart failure if untreated.
Sulodexide is a highly purified glycosaminoglycan (GAG) obtained from porcine digestive mucosa and is composed of a mixture of 80% heparan sulfate (an electrophoretically fast moving fraction with a low molecular weight of 7000 Da and affinity for antithrombin III) and 20% dermatan sulfate with a high molecular weight (25,000 Da) and affinity for the heparin II cofactor.