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Deoxyribonucleotide

From Wikipedia, the free encyclopedia
Component of DNA

Adeoxyribonucleotide is anucleotide that containsdeoxyribose. They are themonomeric units of the informationalbiopolymer, deoxyribonucleic acid (DNA). Each deoxyribonucleotide comprises three parts: a deoxyribose sugar (monosaccharide), anitrogenous base, and onephosphoryl group.[1] The nitrogenous bases are eitherpurines orpyrimidines,heterocycles whose structures support the specificbase-pairing interactions that allow nucleic acids to carry information. The base is always bonded to the 1'-carbon of the deoxyribose, an analog ofribose in which thehydroxyl group of the 2'-carbon is replaced with a hydrogen atom. The third component, the phosphoryl group, attaches to the deoxyribose monomer via thehydroxyl group on the 5'-carbon of the sugar.

When deoxyribonucleotides polymerize to form DNA, the phosphate group from one nucleotide will bond to the 3' carbon on another nucleotide, forming aphosphodiester bond viadehydration synthesis. New nucleotides are always added to the 3' carbon of the last nucleotide, so synthesis always proceeds from 5' to 3'.

Deoxyribonucleoside

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Just as anucleoside can be considered as anucleotide without a phosphate group, so too adeoxyribonucleoside is a deoxyribonucleotide without a phosphate.[2] An example isdeoxycytidine.

References

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  1. ^Dorland's Illustrated Medical Dictionary (32nd ed.). Philadelphia: Saunders/Elsevier. 2012. p. 490.ISBN 978-1-4160-6257-8.
  2. ^Deoxyribonucleosides at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

External links

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Nucleic acid constituents
Nucleobase
Nucleoside
Ribonucleoside
Deoxyribonucleoside
Nucleotide
(Nucleoside monophosphate)
Ribonucleotide
Deoxyribonucleotide
Cyclic nucleotide
Nucleoside diphosphate
Nucleoside triphosphate
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