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As Prime Minister, Shmyhal was in charge of handling the response to theCOVID-19 pandemic in Ukraine and conducting the defense of Ukraine during the2022 Russian invasion.[8] On 15 July 2025, Shmyhal submitted his resignation,[9] a day after PresidentVolodymyr Zelenskyy announced a government reshuffle and proposed replacing Shmyhal withYulia Svyrydenko as prime minister.[10] His tenure as prime minister of over five years was the longest in Ukrainian history.[11] After Svyrydenko took office, he was appointed as the defence minister.[12]
From his graduation in 1997 until September 2005, Shmyhal worked as an accountant in various companies.[15] From September 2005 to June 2006, Shmyhal was Deputy General Director of a company called "LA DIS".[15] From June 2006 to August 2008, he was Director for theinvestment company "Comfort-Invest".[15] From September 2008 to September 2009, Shmyhal was General Director of a company called "Rosaninvest LLC".[15]
Shmyhal worked in multiple leading political roles in Ukraine'sLviv Oblast from 2009 until December 2013.[15] Firstly, as the Head of the Department of Economics at theLviv Oblast Administration between 2009 and 2011.[3][15] It is there where he met and worked withOleh Nemchinov who would, in 2020, becomeMinister of the Cabinet of Ministers in theShmyhal Government.[16] Shmyhal then became the Head of the Department of Economics and Industrial Policy for the whole of 2012.[15] In 2013, he was Head of the Department of Economic Development, Investment, Trade and Industry.[15]
Shmyhal replacedOleksiy Honcharuk as the prime minister of Ukraine in March 2020.[24] In 2021, Shmyhal was included in the list of the 100 most influential Ukrainians, according to the weekly magazineFocus.[17] He was ranked 7th in the list.[17]
In January 2024, Ukraine'sNational Agency on Corruption Prevention accused Shmyhal of exposing the identity of awhistleblower who had reported wrongdoing by the head of the Commission for Regulation of Gambling and Lotteries.[25] If Shymhal is found guilty of exposing the identity of a corruption whistleblower, he would be fined and denied the right to hold certain government positions for one year, and be included in the Unified State Register of persons who have committed corruption-related offenses.[25] The prime minister's spokesperson responded, saying that it was not a whistleblower complaint about corruption, but rather, an appeal from an employee about their dissatisfaction with the work of the head of the Commission for Regulation of Gambling and Lotteries and contained no information about anything pertaining to corruption. Shymhal received the appeal in September 2023, and had handled it according to protocol.[26]
On 14 July 2025, Zelenskyy announced his plan to replace Shmyhal withYulia Svyrydenko as prime minister as part of a government reshuffle; Zelenskyy suggested that Shmyhal might becomedefense minister.[27][28] Shmyhal resigned as prime minister the next day,[9] while theVerkhovna Rada accepted his decision on 16 July.[29]
Shmyhal is married to Kateryna Shmyhal. They have two daughters.[15] Kateryna is a former co-owner of theLviv “Kamyanetsky Bakery” and a localnextbike bike rental outlet. She sold her shares in these companies in 2019.[15]