Decoglurant

Clinical data
Other names	RG1578 and RO4995819
ATC code	none
Legal status
Legal status	Development terminated
Identifiers
IUPAC name 5-({7-(Trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}ethynyl)-2-pyridinamine
CAS Number	911115-16-7
PubChemCID	71533696
ChemSpider	32695160
UNII	5VX4P0JKC5
KEGG	D10875
CompTox Dashboard(EPA)	DTXSID001031872
Chemical and physical data
Formula	C21H11F6N5
Molar mass	447.344 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C#CC4=CN=C(C=C4)N)C(F)(F)F
InChI InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29) Key:DMJHZVARRXJSEG-UHFFFAOYSA-N

Decoglurant (INN; development codesRG1578 andRO4995819) is anegative allosteric modulator of themGlu₂ andmGlu₃ receptors which was under development byRoche for theadjunctive treatment ofmajor depressive disorder.^[1][2] Decoglurant progressed as far asphase IIclinical trials^[1][2] but was ultimately discontinued from further development due to disappointing efficacy results.^[3][4]

• Basimglurant
• RO4491533

• Decoglurant – AdisInsight – Springer

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