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Danuglipron

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Chemical compound

Pharmaceutical compound

Danuglipron
Clinical data

Other names	PF-06882961
Legal status
Legal status	Investigational
Identifiers
IUPAC name 2-[[4-[6-[(4-Cyano-2-fluorophenyl)methoxy]pyridin-2-yl]piperidin-1-yl]methyl]-3-[[(2S)-oxetan-2-yl]methyl]benzimidazole-5-carboxylic acid
CAS Number	2230198-02-2
PubChemCID	134611040
ChemSpider	81367976
UNII	DN9IUI24GP
KEGG	D11910
ChEBI	CHEBI:231951
ChEMBL	ChEMBL4518483
CompTox Dashboard(EPA)	DTXSID601101457
Chemical and physical data
Formula	C₃₁H₃₀FN₅O₄
Molar mass	555.610 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N#Cc1ccc(COc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)CC3)n2)c(F)c1
InChI InChI=1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1 Key:HYBAKUMPISVZQP-DEOSSOPVSA-N

Danuglipron is a small-moleculeGLP-1 agonist, formerly under development byPfizer^[1] that, in an oral formulation, was under investigation as a therapy fordiabetes mellitus. Initial results from arandomized controlled trial indicated that it reduced weight and improveddiabetic control. The most commonly reported adverse events were nausea, diarrhea, and vomiting.^[2]^[3] However, in April 2025, Pfizer announced it would abandon further development of Danuglipron due to unpredictable liver toxicity.^[4]

References

[edit]

^Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, et al. (June 2022)."A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor".Journal of Medicinal Chemistry.65 (12):8208–8226.doi:10.1021/acs.jmedchem.1c01856.PMC 9234956.PMID 35647711.
^Saxena AR, Frias JP, Brown LS, Gorman DN, Vasas S, Tsamandouras N, Birnbaum MJ (May 2023)."Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes: A Randomized Clinical Trial".JAMA Network Open.6 (5): e2314493.doi:10.1001/jamanetworkopen.2023.14493.PMC 10203889.PMID 37213102.
^Constantino AK (2023-12-02)."Pfizer's twice-daily weight loss pill joins a long list of obesity drug flops".CNBC. Retrieved2023-12-03.
^Constantino AK (April 14, 2025)."Pfizer scraps daily weight loss pill after liver injury in one patient".CNBC.

Oraldiabetes medication,insulins andinsulin analogues, and other drugs used in diabetes (A10)

Insulins andinsulin analogues

Fast-acting	Insulin aspart Insulin glulisine Insulin lispro
Short-acting	Regular insulin^#
Long-acting	Insulin detemir^# Insulin glargine^# (+lixisenatide) NPH insulin Lente insulin^‡ Ultralente insulin^‡
Ultra-long-acting	Insulin degludec^# (+insulin aspart,+liraglutide) Insulin icodec^† (+semaglutide)
Inhalable	Exubera^‡ Afrezza
Oral	Insulin tregopil^†

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Non-insulins

Insulin sensitizers

Biguanides	Buformin^‡ Metformin^# Phenformin^‡
TZDs ("-glitazones") andPPAR agonists	Ciglitazone^§ Darglitazone^§ Englitazone^§ Lobeglitazone Netoglitazone^§ Pioglitazone Rivoglitazone^† Rosiglitazone Troglitazone^‡
Dual PPAR agonists	Aleglitazar^† Muraglitazar^§ Saroglitazar Tesaglitazar^§
Amylin analogues andDACRAs	Cagrilintide^§ Pramlintide

Secretagogues

K⁺_ATP

Sulfonylureas	1st generation:Acetohexamide Carbutamide Chlorpropamide Glycyclamide Metahexamide Tolazamide Tolbutamide 2nd generation:Glibenclamide (glyburide) Glibornuride Glicaramide Gliclazide^# Glimepiride Glipizide Gliquidone Glisoxepide Glyclopyramide
Meglitinides ("-glinides")	Mitiglinide Nateglinide Repaglinide

GLP-1 receptor agonists

GLP1 poly-agonist peptides	Mazdutide (GLP-1/GCGR) Retatrutide^§ (GLP-1/GIP/GCGR) Tirzepatide (GLP-1/GIP)

DPP-4 inhibitors ("-gliptins")

Other

Aldose reductase inhibitors	Epalrestat Fidarestat^§ Ranirestat^† Tolrestat^‡ Zenarestat^§
Alpha-glucosidase inhibitors	Acarbose Miglitol Voglibose
SGLT2 inhibitors ("-gliflozins")	Canagliflozin Dapagliflozin Empagliflozin^# Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin^§ Sergliflozin^§ Sotagliflozin Tofogliflozin^† Velagliflozin
Other	Benfluorex^‡ Bromocriptine Imeglimin