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| Formula | C16H16N2OS |
| Molar mass | 284.38 g·mol−1 |
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Dacemazine (INN, also known asAhistan andHistantine)[1] is aphenothiazine derivative which acts as ahistamine antagonist at theH1 subtype. First described in 1951, it was never marketed as a drug on its own, although a combination of dacemazine and di-tert-butylnaphthalenesulfonate was sold as anantispasmodic andantitussive under the trade nameCodopectyl.[1] It was also assessed as a possible anticancer drug.[2]
Amide formation betweenphenothiazine (1) andchloroacetyl chloride (2) gives 10-(Chloroacetyl)-phenothiazine [786-50-5] (3). The subsequent displacement of the remaining halogen withdimethylamine (4) completes the synthesis of dacemazine (5).
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