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DSC3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
DSC3
Identifiers
AliasesDSC3, CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP, desmocollin 3
External IDsOMIM:600271;MGI:1194993;HomoloGene:1462;GeneCards:DSC3;OMA:DSC3 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for DSC3
Genomic location for DSC3
Band18q12.1Start30,989,365bp[1]
End31,042,815bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for DSC3
Genomic location for DSC3
Band18 A2|18 11.11 cMStart20,093,987bp[2]
End20,135,408bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of thigh

  • gingival epithelium

  • skin of hip

  • vulva

  • human penis

  • hair follicle

  • nipple

  • skin of arm

  • skin of abdomen

  • oral cavity
Top expressed in
  • epidermis

  • skin of external ear

  • hair follicle

  • skin of back

  • skin of abdomen

  • lip

  • molar

  • mesenteric lymph nodes

  • cornea

  • conjunctival fornix
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1825

13507

Ensembl

ENSG00000134762

ENSMUSG00000059898

UniProt

Q14574

P55850

RefSeq (mRNA)

NM_024423
NM_001941

NM_001291809
NM_007882

RefSeq (protein)

NP_001932
NP_077741

NP_001278738
NP_031908

Location (UCSC)Chr 18: 30.99 – 31.04 MbChr 18: 20.09 – 20.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Desmocollin-3 is aprotein that in humans is encoded by theDSC3gene.[5][6][7]

Gene

[edit]

The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[7]

Function

[edit]

Desmocollin-3 is a calcium-dependentglycoprotein that is a member of thedesmocollin subfamily of thecadherin superfamily. Thesedesmosomal family members, along with thedesmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation.[7] The loss of these components leads to a lack of adhesion and a gain of cellular mobility.[8]

Clinical significance

[edit]

Breast cancer

[edit]

Through the process ofepigeneticsilencing, the expression of the desmocollin-3 protein is down regulated in manybreast cancers.[8]

Hereditary hypotrichosis

[edit]

Aconsanguineous Afghan family in which 3 sisters, 12 to 18 years of age, and their 5-year-old brother displayed features of hereditaryhypotrichosis, associated with vesicles on the scalp and skin.[9] At birth, scalp hair was present, and after ritual shaving at 1 week of age, scalp hair grew back; however, the hair was fragile and began falling out at 2 to 3 months of age, eventually leaving only sparse hair on the scalp. Vesicles that were less than 1 cm in diameter were observed on the scalp and skin of most of the body, occasionally disappearing but then reappearing; intermittently, the vesicles would burst with a release of fluid, leaving scars on the site that took 3 to 4 months to heal. There were no mucosal vesicles. Upon examination, the affected individuals were nearly devoid of eyebrows, eyelashes, axillary hair, and body hair. Teeth, nails, palms, soles, sweating, and hearing were normal, as was electrocardiography. SerumIgA,IgE, andIgD were measured in 1 individual and showed no change compared to controls. The parents were clinically unaffected. A scalp biopsy of the 18-year-old sister showed slight follicular plugging, mild perivascular and periadnexal inflammatory cell presence, and normal hair follicles. The sebaceous glands appeared morphologically normal and connected to the hair follicles.[9]

Mapping

[edit]

Genotyping andlinkage analysis of the consanguineous Afghan family resulted in a maximum 2-point load score of 2.68 (theta = 0.0) at markers D18S36 and D18S547. Multipoint analysis generated a maximum load score of 3.30 at marker D18S877.Recombination events defined an 8.30-cM critical interval on chromosome 18q12.1, flanked by markers D18S66 and D18S1139, containing 30 genes.[9]

Molecular genetics

[edit]

A nonsense mutation in the DSC3 gene (600271.0001) mapping to chromosome 18q12.1 was identified in the consanguineous Afghan family with hypotrichosis and recurrent skin vesicles (613102). The unaffected parents and 3 healthy siblings were heterozygous for the mutation, which was not found in 100 unrelated ethnically matched controls.[9] In affected members of this family with hypotrichosis werehomozygous for a 2129T-G transversion in exon 14 of the DSC3 gene, resulting in a leu710-to-ter (L710X; Ayub et al. 2009) substitution at the junction of the transmembrane and the C-terminal cytoplasmic domain, predicted to cause premature termination and nonsense mediated decay of the mRNA or instability of the truncated protein. The unaffected parents and 3 healthy siblings were heterozygous for the mutation, which was not found in 100 unrelated ethnically matched controls.[9]

Interactions

[edit]

DSC3 has been shown tointeract withPKP3.[10]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000134762Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000059898Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Amagai M, Wang Y, Minoshima S, Kawamura K, Green KJ, Nishikawa T, Shimizu N (Jul 1995). "Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12".Genomics.25 (1):330–2.doi:10.1016/0888-7543(95)80154-E.PMID 7774948.
  6. ^Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, et al. (Jun 1993)."Nomenclature of the desmosomal cadherins"(PDF).J Cell Biol.121 (3):481–3.doi:10.1083/jcb.121.3.481.PMC 2119574.PMID 8486729.
  7. ^abc"Entrez Gene: DSC3 desmocollin 3".
  8. ^abOshiro MM, Kim CJ, Wozniak RJ, Junk DJ, Muñoz-Rodríguez JL, Burr JA, Fitzgerald M, Pawar SC, Cress AE, Domann FE, Futscher BW (2005)."Epigenetic silencing of DSC3 is a common event in human breast cancer".Breast Cancer Res.7 (5): R669–80.doi:10.1186/bcr1273.PMC 1242132.PMID 16168112.
  9. ^abcdeAyub M, Basit S, Jelani M, Ur Rehman F, Iqbal M, Yasinzai M, Ahmad W (October 2009)."A Homozygous Nonsense Mutation in the Human Desmocollin-3 (DSC3) Gene Underlies Hereditary Hypotrichosis and Recurrent Skin Vesicles".Am. J. Hum. Genet.85 (4):515–20.doi:10.1016/j.ajhg.2009.08.015.PMC 2756559.PMID 19765682.
  10. ^Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003)."Defining desmosomal plakophilin-3 interactions".J. Cell Biol.161 (2):403–16.doi:10.1083/jcb.200303036.PMC 2172904.PMID 12707304.

Further reading

[edit]
Calcium-independent
IgSF CAM
Integrins
Calcium-dependent
Cadherins
Classical
Desmosomal
Protocadherin
Unconventional/ungrouped
Selectins
Other
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