Dipeptidyl-peptidase 3 is anenzyme that in humans is encoded by theDPP3gene.[5][6]
This gene encodes a protein that is a member of the S9B family in clan SC of theserine proteases. Thiscytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-prolinedipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from theN-termini of proteins. Increased activity of this protein is associated withendometrial andovarian cancers. Alternate transcriptional splice variants have been characterized.[7]
Dipeptidyl-peptidase 3 has been found to act as a myocardial depressant factor.Procizumab, a specific antibody for dipeptidyl-peptidase 3, was found to improve cardiac and renal function in a mouse model ofheart failure.[8] In human studies, higher levels of circulating DPP3 protein incardiogenic shock patients indicated a more severe disease course, with a higher risk ofrefractory cardiogenic shock and death.[9][10]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
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Simaga S, Babić D, Osmak M, et al. (1998). "Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue".Eur. J. Cancer.34 (3):399–405.doi:10.1016/S0959-8049(97)00401-2.PMID9640230.
Fukasawa K, Fukasawa KM, Iwamoto H, et al. (1999). "The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme".Biochemistry.38 (26):8299–303.doi:10.1021/bi9904959.PMID10387075.
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