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DNAJB9

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

DNAJB9

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2CTR

Identifiers

Aliases

DNAJB9, ERdj4, MDG-1, MDG1, MST049, MSTP049, DnaJ heat shock protein family (Hsp40) member B9

External IDs

OMIM:602634;MGI:1351618;HomoloGene:32155;GeneCards:DNAJB9;OMA:DNAJB9 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q31.1\|14q24.2-q24.3	Start	108,569,867bp^[1]
Band	7q31.1\|14q24.2-q24.3	End	108,574,850bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 B2	Start	44,252,342bp^[2]
Band	12\|12 B2	End	44,257,109bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Epithelium of choroid plexus

cartilage tissue

body of pancreas

kidney tubule

beta cell

germinal epithelium

corpus epididymis

glomerulus

decidua

metanephric glomerulus

Top expressed in

seminal vesicula

islet of Langerhans

gastrula

olfactory epithelium

decidua

parotid gland

ciliary body

median eminence

paraventricular nucleus of hypothalamus

supraoptic nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	misfolded protein binding protein binding Hsp70 protein binding chaperone binding
Cellular component	endoplasmic reticulum lumen endoplasmic reticulum membrane extracellular exosome nucleolus endoplasmic reticulum cytoplasm
Biological process	IRE1-mediated unfolded protein response ubiquitin-dependent ERAD pathway immunoglobulin production response to unfolded protein B cell differentiation response to endoplasmic reticulum stress negative regulation of IRE1-mediated unfolded protein response
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


4189


27362

Ensembl


ENSG00000128590


ENSMUSG00000014905

UniProt


Q9UBS3


Q9QYI6

RefSeq (mRNA)


NM_012328


NM_013760

RefSeq (protein)


NP_036460


NP_038788

Location (UCSC)

Chr 7: 108.57 – 108.57 Mb

Chr 12: 44.25 – 44.26 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DnaJ homolog subfamily B member 9 is aprotein that in humans is encoded by theDNAJB9gene.^[5]^[6]^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000128590 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000014905 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Prols F, Liehr T, Rinke R, Rautenstrauss B (Apr 1998). "Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2→q24.3 by fluorescence in situ hybridization".Cytogenet Cell Genet.79 (1–2):149–50.doi:10.1159/000134706.PMID 9533036.
^Ohtsuka K, Hata M (Jan 2001)."Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature".Cell Stress & Chaperones.5 (2):98–112.doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025).PMC 312896.PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
^"Entrez Gene: DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9".

Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (2001)."Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells".Genome Res.10 (10):1546–60.doi:10.1101/gr.140200.PMC 310934.PMID 11042152.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (2001)."Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs".Genome Res.11 (3):422–35.doi:10.1101/gr.GR1547R.PMC 311072.PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing".EMBO Rep.1 (3):287–92.doi:10.1093/embo-reports/kvd058.PMC 1083732.PMID 11256614.
Pröls F, Mayer MP, Renner O, Czarnecki PG, Ast M, Gässler C, et al. (2001). "Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis".Exp. Cell Res.269 (1):42–53.doi:10.1006/excr.2001.5294.PMID 11525638.
Shen Y, Meunier L, Hendershot LM (2002)."Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress".J. Biol. Chem.277 (18):15947–56.doi:10.1074/jbc.M112214200.PMID 11836248.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, et al. (2003)."Human Chromosome 7: DNA Sequence and Biology".Science.300 (5620):767–72.Bibcode:2003Sci...300..767S.doi:10.1126/science.1083423.PMC 2882961.PMID 12690205.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (2003)."The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment".Genome Res.13 (10):2265–70.doi:10.1101/gr.1293003.PMC 403697.PMID 12975309.
Berger BJ, Müller TS, Buschmann IR, Peters K, Kirsch M, Christ B, et al. (2003). "High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells".Exp. Cell Res.290 (1):82–92.doi:10.1016/S0014-4827(03)00316-1.PMID 14516790.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Lin KT, Lu RM, Tarn WY (2004)."The WW Domain-Containing Proteins Interact with the Early Spliceosome and Participate in Pre-mRNA Splicing In Vivo".Mol. Cell. Biol.24 (20):9176–85.doi:10.1128/MCB.24.20.9176-9185.2004.PMC 517884.PMID 15456888.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome".Cell.122 (6):957–68.doi:10.1016/j.cell.2005.08.029.hdl:11858/00-001M-0000-0010-8592-0.PMID 16169070.S2CID 8235923.

v t e PDB gallery
2ctr: Solution structure of J-domain from human DnaJ subfamily B member 9

Posttranslational modification

Chaperones/
protein folding

Heat shock proteins/ Chaperonins	Hsp10/GroES Hsp27 Hsp47 HSP60/GroEL Hsp40/DnaJ A1 A2 A3 B1 B2 B11 B4 B6 B9 C1 C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α₁ α₂ β ER TRAP1
Other	Alpha crystallin Clusterin Survival of motor neuron SMN1 SMN2

Protein targeting

Ubiquitin
(ubiquitylation)

E1Ubiquitin-activating enzyme
- UBA1
- UBA2
- UBA3
- UBA5
- UBA6
- UBA7
- ATG7
- NAE1
- SAE1

E2Ubiquitin-conjugating enzyme
- A
- B
- C
- D1
- D2
- D3
- E1
- E2
- E3
- G1
- G2
- H
- I
- J1
- J2
- K
- L1
- L2
- L3
- L4
- L6
- M
- N
- O
- Q1
- Q2
- R1 (CDC34)
- R2
- S
- V1
- V2
- Z

E3Ubiquitin ligase
- VHL
- Cullin
- CBL
- MDM2
- FANCL
- UBR1

Ubiquitin-like proteins
(UBL)

SUMO protein (SUMOylation)	E1 SUMO-activating enzyme SAE1 SAE2 E2 SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4
Other	ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein

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