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DMeOB

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Chemical compound

Pharmaceutical compound

DMeOB
Identifiers


IUPAC name 1-(3-methoxyphenyl)-N-[(3-methoxyphenyl)methylideneamino]methanimine
CAS Number	40252-74-2^Y
PubChemCID	6891506
ChemSpider	5277863^N
CompTox Dashboard(EPA)	DTXSID10425967
ECHA InfoCard	100.164.778
Chemical and physical data
Formula	C₁₆H₁₆N₂O₂
Molar mass	268.316 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COc2cc(ccc2)C=NN=Cc1cccc(OC)c1
InChI InChI=1S/C16H16N2O2/c1-19-15-7-3-5-13(9-15)11-17-18-12-14-6-4-8-16(10-14)20-2/h3-12H,1-2H3/b17-11+,18-12+^N Key:FBNPHFBYHYNMHC-JYFOCSDGSA-N^N
^NY (what is this?) (verify)

DMeOB is a drug used in scientific research which acts as anegative allosteric modulator of themetabotropic glutamate receptor subtypemGluR5.^[1]

^O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL (September 2003). "A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5".Molecular Pharmacology.64 (3):731–40.doi:10.1124/mol.64.3.731.PMID 12920211.

mGluR₁Tooltip Metabotropic glutamate receptor 1	Agonists:ACPD DHPG Glutamate Ibotenic acid Quisqualic acid Ro01-6128 Ro67-4853 Ro67-7476 VU-71 Theanine Antagonists:BAY 36-7620 CPCCOEt Cyclothiazide LY-367,385 LY-456,236 MCPG NPS-2390
mGluR₅Tooltip Metabotropic glutamate receptor 5	Agonists:ACPD ADX-47273 CDPPB CHPG DFB DHPG Glutamate Ibotenic acid Quisqualic acid VU-1545;Positive allosteric modulators:LSN2463359 Antagonists:CTEP DMeOB LY-344,545 Mavoglurant MCPG NPS-2390 Remeglurant SIB-1757 SIB-1893;Negative allosteric modulators:AZD9272 Basimglurant Dipraglurant Fenobam GRN-529 MPEP MTEP Raseglurant

mGluR₂Tooltip Metabotropic glutamate receptor 2

mGluR₃Tooltip Metabotropic glutamate receptor 3

mGluR₄Tooltip Metabotropic glutamate receptor 4	Agonists:Glutamate L-AP4 LSP2-9166 PHCCC VU-001,171 VU-0155,041;Positive allosteric modulators:Foliglurax MPEP Antagonists:CPPG MAP4 MPPG MSOP MTPG UBP-1112
mGluR₆Tooltip Metabotropic glutamate receptor 6	Agonists:Glutamate L-AP4 Antagonists:CPPG MAP4 MPPG MSOP MTPG UBP-1112
mGluR₇Tooltip Metabotropic glutamate receptor 7	Agonists:AMN082 Glutamate L-AP4 LSP2-9166 Antagonists:CPPG MAP4 MMPIP MPPG MSOP MTPG UBP-1112 XAP044;Negative allosteric modulators:ADX71743
mGluR₈Tooltip Metabotropic glutamate receptor 8	Agonists:DCPG Glutamate L-AP4;Positive allosteric modulators:AZ12216052 Antagonists:CPPG MAP4 MPPG MSOP MTPG UBP-1112

See also:Receptor/signaling modulators •Ionotropic glutamate receptor modulators •Glutamate metabolism/transport modulators

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