Many vertebratehomeobox-containing genes have been identified on the basis of their sequence similarity withDrosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform (BP1) functions as a repressor of thebeta-globin gene while the other isoform lacks that function.[5]
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Quinn LM, Latham SE, Kalionis B (1998). "A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta".Placenta.19 (1):87–93.doi:10.1016/S0143-4004(98)90103-5.PMID9481790.
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Haga SB, Fu S, Karp JE, Ross DD, Williams DM, Hankins WD, Behm F, Ruscetti FW, Chang M (2000). "BP1, a new homeobox gene, is frequently expressed in acute leukemias".Leukemia.14 (11):1867–75.doi:10.1038/sj.leu.2401912.PMID11069021.S2CID24099984.
Fu S, Stevenson H, Strovel JW, Haga SB, Stamberg J, Do K, Berg PE (2002). "Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene".Gene.278 (1–2):131–9.doi:10.1016/S0378-1119(01)00716-8.PMID11707330.
Neufing PJ, Kalionis B, Horsfall DJ, Ricciardelli C, Stahl J, Vivekanandan S, Raymond W, Tilley WD (2003). "Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues".Anticancer Res.23 (2B):1479–88.PMID12820413.
