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DIDS

From Wikipedia, the free encyclopedia
DIDS
Skeletal formula
Ball-and-stick model
Names
Preferred IUPAC name
2,2′-(Ethene-1,2-diyl)bis(5-isothiocyanatobenzene-1-sulfonic acid)
Other names
5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid
Identifiers
3D model (JSmol)
AbbreviationsDIDS
6543839
ChEBI
ChemSpider
ECHA InfoCard100.152.489Edit this at Wikidata
KEGG
MeSH4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid
UNII
  • InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)
    Key: YSCNMFDFYJUPEF-UHFFFAOYSA-N
  • OS(=O)(=O)C1=C(C=CC2=C(C=C(C=C2)N=C=S)S(O)(=O)=O)C=CC(=C1)N=C=S
Properties
C16H10N2O6S4
Molar mass454.50 g·mol−1
Melting point400 °C (752 °F; 673 K)
logP4.72
Acidity (pKa)−3.21, −1.428, −0.37, 0.23
Basicity (pKb)13.77, 14.37, 15.425, 17.21
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

4,4′-Diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS) is ananion exchangeinhibitor,[1] blocking reversibly, and later irreversibly,exchangers such aschloride-bicarbonate exchanger.[2]

References

[edit]
  1. ^Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS",Journal of Membrane Biology,92 (3):195–205,doi:10.1007/BF01869388,PMID 3783658,S2CID 19244281
  2. ^Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange RegulatesIntracellular pH of Embryos but Not Oocytes of the Hamster",Biology of Reproduction,61 (2):452–457,doi:10.1095/biolreprod61.2.452,PMID 10411526
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
ASTTooltip Aspartate aminotransferase
ALTTooltip Alanine aminotransferase
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase

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