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DDX6

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
DDX6
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1VEC,2WAX,2WAY,4CRW,4CT4,4CT5,5ANR

Identifiers
AliasesDDX6, HLR2, P54, RCK, DEAD-box helicase 6, IDDILF, Rck/p54
External IDsOMIM:600326;MGI:104976;HomoloGene:3238;GeneCards:DDX6;OMA:DDX6 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for DDX6
Genomic location for DDX6
Band11q23.3Start118,747,763bp[1]
End118,791,164bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for DDX6
Genomic location for DDX6
Band9 A5.2|9 24.84 cMStart44,516,189bp[2]
End44,552,028bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • Achilles tendon

  • ventricular zone

  • middle temporal gyrus

  • superior vestibular nucleus

  • amniotic fluid

  • internal globus pallidus

  • vena cava

  • lateral nuclear group of thalamus

  • trigeminal ganglion
Top expressed in
  • aortic valve

  • ascending aorta

  • gastrula

  • saccule

  • otic placode

  • supraoptic nucleus

  • mesenteric lymph nodes

  • otic vesicle

  • lacrimal gland

  • superior cervical ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1656

13209

Ensembl

ENSG00000110367

ENSMUSG00000032097

UniProt

P26196

P54823

RefSeq (mRNA)

NM_001257191
NM_004397

NM_001110826
NM_007841
NM_181324
NM_001357702
NM_001357703

RefSeq (protein)

NP_001244120
NP_004388

NP_001104296
NP_031867
NP_851841
NP_001344631
NP_001344632

Location (UCSC)Chr 11: 118.75 – 118.79 MbChr 9: 44.52 – 44.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable ATP-dependent RNA helicase DDX6 is anenzyme that in humans is encoded by theDDX6gene.[5][6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration ofRNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, andribosome andspliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved inembryogenesis,spermatogenesis, andcellular growth and division. This gene encodes a DEAD box protein. It may contribute to thecell proliferation andcarcinogenesis.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000110367Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000032097Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Lu D, Yunis JJ (Jun 1992)."Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3".Nucleic Acids Res.20 (8):1967–72.doi:10.1093/nar/20.8.1967.PMC 312313.PMID 1579499.
  6. ^ab"Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6".

Further reading

[edit]
PDB gallery
  • 1vec: Crystal structure of the N-terminal domain of rck/p54, a human DEAD-box protein
    1vec: Crystal structure of the N-terminal domain of rck/p54, a human DEAD-box protein


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