Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

DCW234

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
DCW234
Clinical data
Other namesButyl 4-(butyryloxy)benzoate
Identifiers
  • butyl 4-butanoyloxybenzoate
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC15H20O4
Molar mass264.321 g·mol−1
3D model (JSmol)
  • CCCCOC(=O)C1=CC=C(C=C1)OC(=O)CCC
  • InChI=1S/C15H20O4/c1-3-5-11-18-15(17)12-7-9-13(10-8-12)19-14(16)6-4-2/h7-10H,3-6,11H2,1-2H3
  • Key:LMJDPYAJKHNPHR-UHFFFAOYSA-N

DCW234, also known asbutyl 4-(butyryloxy)benzoate, is asyntheticnonsteroidalestrogen and aselectiveagonist of theERβ.[1][2][3] It shows modestselectivity in terms ofaffinity andtransactivation for the ERβ over theERα.[1] Its affinity for the ERβ was 3.43 μM and for the ERα was 22.5 μM, while it activated the ERβ and ERα withEC50 values of 1.71–2.5 μM and 19.8–22.5 μM, respectively.[1] As such, its binding selectivity for the ERβ over the ERα was 7-fold and itsfunctional selectivity for the ERβ over the ERα was between 10- and 13-fold.[1]

See also

[edit]

References

[edit]
  1. ^abcdLin Z, Shen H, Huang J, Chen S, Chen L, Chen J, Liu G, Jiang H, Shen X (2008). "Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor beta agonist and induces GLUT4 expression in CHO-K1 cells".J. Steroid Biochem. Mol. Biol.110 (1–2):150–6.doi:10.1016/j.jsbmb.2008.03.028.PMID 18455388.S2CID 206496235.
  2. ^Minutolo F, Macchia M, Katzenellenbogen BS, Katzenellenbogen JA (2011). "Estrogen receptor β ligands: recent advances and biomedical applications".Med Res Rev.31 (3):364–442.doi:10.1002/med.20186.PMID 19967775.S2CID 3841877.
  3. ^Serock MR, Wells AK, Khalil RA (2008). "Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause".Recent Pat Cardiovasc Drug Discov.3 (3):165–86.doi:10.2174/157489008786263970.PMID 18991792.


ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown
Retrieved from "https://en.wikipedia.org/w/index.php?title=DCW234&oldid=1270037174"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp