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| Names | |
|---|---|
| IUPAC name [[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate | |
| Other names dATP, 2'-deoxyadenosine triphosphate | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
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| ECHA InfoCard | 100.016.058 |
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| Properties | |
| C10H16N5O12P3 | |
| Molar mass | 491.181623 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Deoxyadenosine triphosphate (dATP) is anucleotide used in cells forDNA synthesis (or replication), as a substrate ofDNA polymerase.[1]
Deoxyadenosine triphosphate is produced fromDNA by the action ofnuclease P1,adenylate kinase, andpyruvate kinase.[2]
High levels of dATP can betoxic and result in impairedimmune function, since dATP acts as anoncompetitive inhibitor for the DNA synthesisenzymeribonucleotide reductase. Patients withadenosine deaminase deficiency (ADA) tend to have elevatedintracellular dATP concentrations becauseadenosine deaminase normally curbsadenosine levels by converting it intoinosine.[3][4] Deficiency of this deaminase also causes immunodeficiency.[5]
Incardiacmyosin, dATP is an alternative to ATP as an energy substrate for facilitatingcross-bridge formation.[6][7]
