Movatterモバイル変換

[0]ホーム

Jump to content

DAPK2

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

DAPK2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1WMK,1WRZ,1Z9X,1ZUZ,1ZWS,2A27,2A2A,2CKE

Identifiers

Aliases

DAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2

External IDs

OMIM:616567;MGI:1341297;HomoloGene:74940;GeneCards:DAPK2;OMA:DAPK2 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q22.31	Start	63,907,036bp^[1]
Band	15q22.31	End	64,072,033bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 C\|9 35.75 cM	Start	66,158,223bp^[2]
Band	9 C\|9 35.75 cM	End	66,272,242bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of thyroid gland

left lobe of thyroid gland

right auricle of heart

right lung

gastrocnemius muscle

muscle of thigh

upper lobe of left lung

left ventricle

blood

sural nerve

Top expressed in

muscle of thigh

membranous bone

body of femur

lumbar spinal ganglion

Dermatocranium

maxilla

right lung

right lung lobe

tibiofemoral joint

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity calmodulin binding kinase activity protein serine/threonine kinase activity protein binding identical protein binding ATP binding
Cellular component	cytoplasm autophagosome lumen cytoplasmic vesicle Golgi apparatus intracellular membrane-bounded organelle nucleus
Biological process	regulation of apoptotic process intracellular signal transduction regulation of intrinsic apoptotic signaling pathway phosphorylation protein phosphorylation positive regulation of eosinophil chemotaxis regulation of autophagy anoikis positive regulation of neutrophil chemotaxis protein autophosphorylation neutrophil migration apoptotic process peptidyl-serine phosphorylation peptidyl-threonine phosphorylation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


23604


13143

Ensembl


ENSG00000035664


ENSMUSG00000032380

UniProt


Q9UIK4


Q8VDF3

RefSeq (mRNA)

NM_014326 NM_001363730 NM_001384997 NM_001384998 NM_001384999
NM_001385000


NM_010019

RefSeq (protein)


NP_055141 NP_001350659


NP_034149 NP_001391612

Location (UCSC)

Chr 15: 63.91 – 64.07 Mb

Chr 9: 66.16 – 66.27 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Death-associated protein kinase 2 is anenzyme that in humans is encoded by theDAPK2gene.^[5]^[6]

This gene encodes a protein that belongs to theserine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conservedcalmodulin-binding domain with significant similarity to that ofdeath-associated protein kinase 1 (DAPK1), a positive regulator ofprogrammed cell death. Gene overexpression induces cellapoptosis. It uses multiple polyadenylation sites.^[6]

The DAPK2 mRNA may undergo alternative splicing to produce aDAPK3-like encoding transcript.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000035664 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000032380 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, et al. (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity".Oncogene.18 (23):3471–3480.doi:10.1038/sj.onc.1202701.PMID 10376525.S2CID 19035227.
^^a ^b"Entrez Gene: DAPK2 death-associated protein kinase 2".
^Shoval Y, Berissi H, Kimchi A, Pietrokovski S (Mar 2011)."New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform".PLOS ONE.6 (2) e17344.Bibcode:2011PLoSO...617344S.doi:10.1371/journal.pone.0017344.PMC 3050894.PMID 21408167.

Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A (Feb 2000)."Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis".Molecular and Cellular Biology.20 (3):1044–1054.doi:10.1128/MCB.20.3.1044-1054.2000.PMC 85221.PMID 10629061.
Shani G, Henis-Korenblit S, Jona G, Gileadi O, Eisenstein M, Ziv T, et al. (Mar 2001)."Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding".The EMBO Journal.20 (5):1099–1113.doi:10.1093/emboj/20.5.1099.PMC 145456.PMID 11230133.
Wong TS, Chang HW, Tang KC, Wei WI, Kwong DL, Sham JS, et al. (Feb 2002). "High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients".Clinical Cancer Research.8 (2):433–437.PMID 11839660.
Chan MW, Chan LW, Tang NL, Tong JH, Lo KW, Lee TL, et al. (Feb 2002). "Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients".Clinical Cancer Research.8 (2):464–470.PMID 11839665.
Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A (Apr 2002)."DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death".The Journal of Cell Biology.157 (3):455–468.doi:10.1083/jcb.200109094.PMC 2173279.PMID 11980920.
Satoh A, Toyota M, Itoh F, Kikuchi T, Obata T, Sasaki Y, et al. (Jun 2002)."DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers".British Journal of Cancer.86 (11):1817–1823.doi:10.1038/sj.bjc.6600319.PMC 2375414.PMID 12087472.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".Science.307 (5715):1621–1625.Bibcode:2005Sci...307.1621B.doi:10.1126/science.1105776.PMID 15761153.S2CID 39457788.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (Nov 2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127 (3):635–648.doi:10.1016/j.cell.2006.09.026.PMID 17081983.
Rizzi M, Tschan MP, Britschgi C, Britschgi A, Hugli B, Grob TJ, et al. (Jun 2007)."The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells".Journal of Leukocyte Biology.81 (6):1599–1608.doi:10.1189/jlb.0606400.PMID 17347302.

v t e PDB gallery
1wmk: Human death-associated kinase DRP-1, mutant S308D d40 1z9x: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 3 monomers in the asymmetric unit 1zws: Crystal structure of the catalytic domain of human DRP-1 kinase 2a27: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit 2a2a: High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase 2cke: HUMAN DEATH-ASSOCIATED DRP-1 KINASE IN COMPLEX WITH INHIBITOR

PDB gallery

1wmk: Human death-associated kinase DRP-1, mutant S308D d40
1z9x: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 3 monomers in the asymmetric unit
1zws: Crystal structure of the catalytic domain of human DRP-1 kinase
2a27: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit
2a2a: High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase
2cke: HUMAN DEATH-ASSOCIATED DRP-1 KINASE IN COMPLEX WITH INHIBITOR

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

This article on agene on humanchromosome 15 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=DAPK2&oldid=1313487366"

Categories:

Hidden categories:

[8]ページ先頭

Movatterモバイル変換

References

Further reading