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| Other names | dextro-N-propargyl-N-methylamphetamine |
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| Formula | C13H17N |
| Molar mass | 187.286 g·mol−1 |
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| Chirality | Dextrorotatoryenantiomer |
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d-Deprenyl, also known as ordextro-N-propargyl-N-methylamphetamine, is anMAO-Binhibitor that metabolizes intod-amphetamine andd-methamphetamine and is therefore also anorepinephrine–dopamine releasing agent.[1][2][3][4][5] It is one of the twoenantiomers ofdeprenyl and is the opposite enantiomer ofl-deprenyl (selegiline).
l-Deprenyl, also an MAO-B inhibitor, metabolizes tol-amphetamine andl-methamphetamine, which are bothnorepinephrine releasing agents. In contrast,d-deprenyl additionally hasdopaminergic effects and has been found to bereinforcing in scientific research, whereasl-deprenyl is not known to have any appreciable psychological reinforcement.[6][7]
In addition to its actions as an MAO-B inhibitor and NDRA,d-deprenyl has been found to bind with highaffinity to theσ1 receptor (Ki = 79 nM) similarly to various other amphetamine derivatives.[8][9] Itsl-isomer, selegiline, binds with 3.5-fold lower affinity in comparison.[8][9]
