 | |
 Headquarters in South San Francisco | |
| Company type | Public |
|---|---|
| Industry | Biotechnology industry |
| Founded | 1997; 28 years ago (1997) |
| Founders | |
| Headquarters | , U.S. |
Key people | |
| Products |
|
| Revenue |  US$7.53 million (2023) |
| US$(496.2 million) (2023) | |
| US$(526.2 million) (2023) | |
| Total assets | US$824.3 million (2023) |
Number of employees | 423 (December 2023) |
| Website | cytokinetics |
| Footnotes / references Financials as of December 31, 2023[update].[1] | |
Cytokinetics, Incorporated, is abiopharmaceutical company based inSouth San Francisco, California, that develops muscle activators and muscle inhibitors as potential treatments for people with diseases characterized by impaired or declining muscle function.
Cytokinetics was founded in 1997 byJames Spudich,Ronald Vale, James Sabry andLawrence S.B. Goldstein, four scientists atStanford,UCSD, andUCSF.[2] Operations began in 1998.
Initially, Cytokinetics focused on the possible pharmacological targets and areas of application of drugs based on cytoskeletal proteins.[2] Eventually, the company narrowed its focus to the mechanics of muscle biology.[2] Cytokinetics develops muscle activators and muscle inhibitors to improve muscle function in patients with cardiovascular and neuromuscular diseases.[3][4]
In 2004 the company completed itsinitial public offering (IPO).[5]
In January 2007, Cytokinetics named Robert I. Blum as president and CEO.[6] Prior to this, Blum has been involved in the company since its founding, with roles in business development, corporate development and R&D.[7]
In 2013, Cytokinetics finalized a licensing and discovery deal with Astellas to research treatment for muscle weakness and fatigue.[8]
In July 2020, Ji Xing Pharmaceuticals signed a financing deal with Cytokinetics, which included the rights to commercialize the drug designed to treat hypertrophic cardiomyopathies,aficamten, in China and certain neighboring regions.[9]
Omecamtiv mecarbil is a cardiac muscle activator for the potential treatment ofheart failure.[10][11] In May 2020,omecamtiv mecarbil was granted fast track designation by theFDA for the treatment of chronic HF with reduced ejection fraction.[12]Amgen purchased an option onomecamtiv mecarbil in 2006, and the two companies extended their partnership several times.[2] In June 2013, Cytokinetics and Amgen expanded their licensing deal foromecamtiv mecarbil to include Japan. In November 2020 Amgen elected to terminate the collaboration, effective May 20, 2021, and Cytokinetics regained worldwide rights to develop and commercialize omecamtiv mecarbil.[13][14]
Reldesemtiv (previously known as CK-2127107) is a next-generation fast skeletal muscle troponin activator (FSTA) that has undergone clinical trials forALS.[15]
Aficamten (previously known as CK-3773274) is an oral, small-molecule myosin inhibitor, to treathypertrophic cardiomyopathy (HCM).[3][16]