Protein-coding gene in the species Homo sapiens
G2/mitotic-specific cyclin-B2 is aprotein that in humans is encoded by theCCNB2 gene .
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[ 5]
Cyclin B2 has been shown tointeract withTGF beta receptor 2 .[ 6]
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