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Crotylsarin

From Wikipedia, the free encyclopedia
Crotylsarin
Names
Preferred IUPAC name
(2E)-But-2-en-1-yl methylphosphonofluoridate
Other names
CRS
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C5H10FO2P/c1-3-4-5-8-9(2,6)7/h3-4H,5H2,1-2H3/b4-3+
    Key: CSVWTPQEXJLYLO-ONEGZZNKSA-N
  • C/C=C/COP(=O)(C)F
Properties
C5H10FO2P
Molar mass152.105 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Crotylsarin (CRS) is an extremely toxicorganophosphatenerve agent of the G-series.[1] Like other nerve agents, CRS irreversibly inhibitsacetylcholinesterase. However, since the inhibited enzyme ages so rapidly, it can't be reactivated bycholinesterase reactivators.[2][3]

See also

[edit]

References

[edit]
  1. ^Worek, Franz; Wille, Timo; Koller, Marianne; Thiermann, Horst (27 June 2016). "Toxicology of organophosphorus compounds in view of an increasing terrorist threat".Archives of Toxicology.90 (9):2131–2145.Bibcode:2016ArTox..90.2131W.doi:10.1007/s00204-016-1772-1.PMID 27349770.S2CID 15724842.
  2. ^Busker, R.W.; Zijlstra, J.J.; van der Wiel, H.J.; Melchers, B.P.C.; van Helden, H.P.M. (January 1991). "Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the rat".Toxicology.69 (3):331–344.Bibcode:1991Toxgy..69..331B.doi:10.1016/0300-483x(91)90191-3.PMID 1658986.
  3. ^Soukup, O.; Jun, D.; Tobin, G.; Kuca, K. (21 November 2012). "The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors".Archives of Toxicology.87 (4):711–719.doi:10.1007/s00204-012-0977-1.PMID 23179755.S2CID 18252681.
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Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
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