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Cross-coupling partner

From Wikipedia, the free encyclopedia

Incross-coupling reactions, the component reagents are calledcross-coupling partners or simplycoupling partners. These reagents can be further classified according to theirnucleophilic vselectrophilic character:

R-X + R'-Y → R-R' + XY

Typically theelectrophilic coupling partner (R-X) is an aryl halide, but triflates are also used. Nucleophilic coupling (R'-Y) partners are more diverse. In theSuzuki reaction,boronic esters andboronic acids serve asnucleophilic coupling partners.[1] Expanding the scope of coupling partners is a focus methods development inorganic synthesis.[2][3]

References

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  1. ^Kirchhoff, Jan H.; Netherton, Matthew R.; Hills, Ivory D.; Fu, Gregory C. (2002). "Boronic Acids: New Coupling Partners in Room-Temperature Suzuki Reactions of Alkyl Bromides. Crystallographic Characterization of an Oxidative-Addition Adduct Generated under Remarkably Mild Conditions".Journal of the American Chemical Society.124 (46):13662–13663.Bibcode:2002JAChS.12413662K.doi:10.1021/ja0283899.PMID 12431081.
  2. ^Denmark, Scott E.; Hung-Chang Liu, Jack (2011). "Discussion Addendum for: Palladium Catalyzed Cross-Coupling of (Z)-1-Heptenyldimethylsilanol with 4-Iodoanisole: (Z)-(1-Heptenyl)-4-methoxybenzene".Organic Syntheses.88: 102.doi:10.15227/orgsyn.088.0102.
  3. ^Robert M. Williams (2011)."4-Methoxy-4'-nitrophenyl. Recent Advances In The Stille Biaryl Coupling Reaction and Applications in Complex Natural Products Synthesis".Org. Synth.88:197–201.doi:10.15227/orgsyn.088.0197.PMC 3181114.PMID 21960729.
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