He started out atDanubio, being bought byReggina in 2008. He went on to spend the vast majority of his professional career in Spain, in representation of several clubs, includingEspanyol; he signed withMiddlesbrough from England in 2015 and, two years later, joined Girona.
In January 2008, after scoring 19 goals in the2007 Apertura with Danubio, Stuani was signed byReggina in Italy, penning a four-year contract with theSerie A club.[3] He made his official debut on the 12th, playing 30 minutes in a 1–1 away draw againstEmpoli.[4]
When Stuani joined, the club was second from bottom and had the fewest goals scored in the league, followingRolando Bianchi's departure forManchester City in the previous summer – he went scoreless in 12 games, but theReggio Calabria team managed toretain their division status. In2008–09, he scored his only league goal from apenalty kick in the last round, a 1–1 home draw againstSiena,[5] having only appeared in four more matches during the entire season, which ended in top-flight relegation.
For2010–11, Stuani remained in the country and on loan, but moved toLa Liga withLevante.[9] He was used mostly as abackup toFelipe Caicedo,[10] but still contributed eight goals – second-best in the squad – as theValencians easily retained their status, netting twice in a 3–1 home defeat ofMálaga.[11]
In summer 2012, Stuani was linked with a move toDeportivo de La Coruña and even passed his medical[14] but, on 28 August, he signed a four-year contract withEspanyol[15] even though that club and Reggina had initially agreed on aseason-long loan.[2]
On 15 July 2015,Middlesbrough reached an agreement for the transfer of Stuani,[17] with the deal being completed after receiving international clearance on 7 August, for a rumoured€3 million fee.[18] His first appearance in theFootball League Championship occurred on 9 August, as he replacedKike in the 77th minute of an eventual 0–0 away draw againstPreston North End.[19] Three days later he made his first start, in theopening round of theLeague Cup, scoring in each half of a 3–1 win overOldham Athletic atBoundary Park;[20] he scored a brace again in the second round on the 25th, as his team came from behind to win atBurton Albion.[21]
Stuani scored his first league goal on 29 August 2015, concluding a 3–1 victory atSheffield Wednesday.[22] Seventeen days later, he netted twice in a victory of the same margin againstBrentford at theRiverside Stadium.[23]
On 28 December 2015, Stuani finishedStewart Downing's cross in the 44th second for the only goal of the home game against Wednesday, putting Middlesbrough on top of the table.[24] He did not find the net again until the final game ofthe season on the following 7 May, opening a 1–1 home draw withBrighton & Hove Albion which won promotion to thePremier League at the opponents' expense; the goal's worth was valued at £170 million.[25]
On 21 August 2016, Stuani scored his first goals in the top division in his first game in the competition, grabbing a brace againstSunderland in a 2–1 win at theStadium of Light.[26]
On 10 March 2019, Stuani became the club's all-time scorer in the top tier with 38 successful strikes after a 2–3 loss toValencia at theEstadi Montilivi, surpassing former holderJandro;[30] despite totalling 19 duringthe season to repeat the same position in the scoring department, the team succumbed to relegation on the last matchday.[31][32]
Subsequently, a number of clubs approached Stuani for a summer move, most notably championsBarcelona.[33][34] However, he eventually put pen to a contract extension with until 2023.[35] He missed the first two league games due to a groin injury,[36] but scored in his first appearance on 1 September 2019 to help the hosts defeat Málaga 1–0;[37] he added ahat-trick the following weekend, at home to Rayo Vallecano (3–1).[38]
Stuani was selected by managerÓscar Tabárez for the finals in Brazil.[42] He scored in both of Uruguay's warm-up matches for the tournament, the only goal of the game againstNorthern Ireland after coming on at half-time forDiego Forlán,[43] and the second in a 2–0 win overSlovenia.[44] He made histournament debut on 14 June, starting in a 3–1 loss toCosta Rica inFortaleza,[45] and added a further three bench appearances in around-of-16 exit.
Stuani was named in Uruguay's squad the following year, as they attempted to defend their continental crown at the2015 Copa América. He made two substitute appearances inGroup B, in a quarter-final finish.
Stuani was included in the final 23-man squad for the2018 World Cup in Russia.[46] His first match in the competition took place on 30 June, when he replacedEdinson Cavani (who had scored twice) for the final 16 minutes of the 2–1 round-of-16 victory overPortugal.[47] He started in the next match due to injury to the same teammate, and played 59 minutes in the 2–0 defeat againstFrance.[48]
^"El Levante ficha a Stuani" [Levante sign Stuani] (in Spanish). Fichajes. 29 July 2010.Archived from the original on 7 April 2014. Retrieved2 April 2014.
^"El Racing ficha a Stuani" [Racing sign Stuani].Marca (in Spanish). 12 August 2011.Archived from the original on 7 April 2014. Retrieved2 April 2014.
^Estepa, Javier (21 December 2011)."Todo por un penalti tonto" [All because of a foolish penalty].Marca (in Spanish).Archived from the original on 6 June 2014. Retrieved5 June 2014.
^"Principi d'acord per la sortida d'Stuani" [Agreement in principle for the departure of Stuani] (in Catalan). RCD Espanyol. 15 July 2015.Archived from the original on 16 July 2015. Retrieved15 July 2015.
^Pérez, José I. (19 August 2017)."El ADN del Atlético no se ficha" [You can't sign Atlético's DNA].Marca (in Spanish).Archived from the original on 9 February 2018. Retrieved19 August 2017.
^Gracia, Albert (20 May 2018)."El gol en Girona se apellida Stuani" [Goal is named Stuani in Girona].Sport (in Spanish).Archived from the original on 12 June 2018. Retrieved4 June 2018.
^Biescas, Álex (8 September 2019)."A Stuani le da igual el rival o la categoría" [Stuani could not care less about opponent or tier].Diario AS (in Spanish).Archived from the original on 16 September 2019. Retrieved19 September 2019.
^"Uruguay ganó con goles de Salto" [Uruguay won with goals from Salto].La Prensa (in Spanish). 15 November 2012.Archived from the original on 3 April 2018. Retrieved3 April 2018.