The CoviVac shot is given in two doses, 14 days apart. It is transported and stored at normal refrigerated temperatures, of 2 to 8 degreesCelsius (35.6 to 46.4Fahrenheit).[2]
As aninactivated vaccine, CoviVac uses a more traditional technology that is similar to the inactivatedpolio vaccine. Initially, a sample ofSARS-CoV-2 strain AYDAR-1 was isolated by the Chumakov Center at theRussian Academy of Sciences and used to grow large quantities of the virus usingvero cells. From then on, the viruses are soaked in beta-propiolactone, which deactivates them by binding to their genes, while leaving other viral particles intact. The resulting inactivated viruses are then mixed with an aluminium-basedadjuvant.[6]
^Kozlovskaya L, Pinyaeva A, Kovpak A, Gordeichuk I, Volok V, Ignatiev G (1 April 2021)."«КОВИВАК»: инактивированный, но активный" ["COVIVAC": inactivated but active].indicator.ru (Interview) (in Russian). Interviewed by Vodovozov A. Retrieved19 May 2021.
.svg)